Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol YTHDF3 contributors: mct - updated : 06-11-2019
HGNC name YTH N6-methyladenosine RNA binding protein 3
HGNC id 26465
Location 8q12.3      Physical location : 64.081.120 - 64.125.345
Synonym name
  • YTH N(6)-methyladenosine RNA binding protein 3
  • YTH domain family protein 3
    • Synonym symbol(s) FLJ31657
    DNA
    TYPE functioning gene
    STRUCTURE 44.23 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 5317 - 588 - 2017 28106076
    6 - 5202 - 534 - 2017 28106076
    4 - 5085 - 534 - 2017 28106076
    5 - 5095 - 585 - 2017 28106076
    5 - 5010 - 534 - 2017 28106076
    5 - 4931 - 534 - 2017 28106076
    6 - 5071 - 588 - 2017 28106076
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY YTH (YT521-B homology) domain family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • together with YTHDF1 and YTHDF2, YTHDF3 plays critical roles to accelerate metabolism of m6A-modified mRNAs in the cytoplasm
  • new role for YTHDF3 in shaping the selectivity of stress response
  • role of YTHDF3 as a negative regulator of antiviral immunity through the translational promotion of FOXO3 mRNA under homeostatic conditions
  • enzymes important for N6-methyladenosine RNA transmethylation (METTL4, YWHAB, and YTHDF3), regulates the pace of the circadian clock
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • YTHDF3 cooperates with two cofactors, PABP1 and EIF4G2, to promote FOXO3 translation by binding to the translation initiation region of FOXO3 mRNA
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of YTHDF1, YTHDF3 and KIAA1429 predicted poor prognosis in terms of overall survival (OS) in breast cancer (BRC)
    tumoral       loss of function
    METTL14, YTHDF3 and ALKBH5 were downregulated in Colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • upregulation of YTHDF3 was an independent prognostic factor for overall survival (OS) in patients with breast cancer (BRC)
    • Therapy target
    ANIMAL & CELL MODELS