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FLASH GENE
Symbol YTHDF2 contributors: mct - updated : 12-06-2019
HGNC name YTH domain family, member 2
HGNC id 31675
Location 1p35.3      Physical location : 29.063.132 - 29.096.286
Synonym name
  • YTH domain family, member 2
  • high-glucose-regulated protein 8
  • CLL-associated antigen KW-14
  • renal carcinoma antigen NY-REN-2high-glucose-regulated protein 8
  • Synonym symbol(s) HGRG8, NY-REN-2, CAHL
    DNA
    TYPE functioning gene
    STRUCTURE 33.15 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2830 - 579 - 2016 27558897
    5 - 3073 - 579 - 2016 27558897
    4 - 2723 - 529 - 2016 27558897
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestineileum highly
     mouth   highly
    Lymphoid/Immunespleen   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis   
    Skeletonaxial skeletonskullfacemandible 
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa)  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a YTH domain
    HOMOLOGY
    Homologene
    FAMILY YTH (YT521-B homology) domain family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    basic FUNCTION
  • may be playing a role in human longevity
  • in the cytoplasm, N6-methyladenosine (m6A) binding protein YTHDF2 accelerates the decay of m6A-modified transcripts
  • together with YTHDF1 and YTHDF2, YTHDF3 plays critical roles to accelerate metabolism of m6A-modified mRNAs in the cytoplasm
  • YTHDF2 may act as a tumor suppressor to repress cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • YTHDF2 recruits the CCR4-NOT complex through a direct interaction between the YTHDF2 N-terminal region and the SH domain of the CNOT1 subunit, and this recruitment is essential for the deadenylation of m(6)A-containing RNAs by CAF1 and CCR4
  • FMR1 regulates the stability of its m6A-marked mRNA targets through YTHDF2, which could potentially contribute to the molecular pathogenesis of Fragile X syndrome (FXS)
  • YTHDF2 depletion increased the expression and stability of MAP2K4 and MAP4K4 mRNAs
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with RUNX1 in acute myeloid leukemia
    Susceptibility
    Variant & Polymorphism repeat (TG)n microsatellite evidenced an increased homozygosity in centenarians
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    is a unique therapeutic target whose inhibition selectively targets leukemic stem cells (LSCs) while promoting hematopoietic stem cells (HSCs) expansion
    ANIMAL & CELL MODELS