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FLASH GENE
Symbol YTHDC1 contributors: npt - updated : 10-08-2004
HGNC name YTH domain containing 1
HGNC id 30626
Location 4q13.3      Physical location : 6.027 - 69.215.824
Synonym name
  • splicing factor YT521-B
  • putative splicing factor YT521
  • Synonym symbol(s) KIAA1966, YT521, ENSG00000083896, KIAA1966, YT521-B
    DNA
    TYPE functioning gene
    STRUCTURE 39.00 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 6249 85 727 - -
    - - 6195 - 709 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivestomach    
    Nervousbrain    
    Reproductivefemale systemuterus   
     male systemprostate   
    Urinarybladder    
     kidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • YTH domain
  • HOMOLOGY
    interspecies ortholog to rat spicing factor Yt521
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • in YT bodies when is non-phosphorylated and soluble;
  • after phosphorylation is associated with an insoluble nuclear structure in the nucleoplasm
  • basic FUNCTION
  • playing a role in the changement of splice site selection, in a concentration -dependent manner (abolished ability wehn is in an insoluble nuclear form)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • tyrosine phosphorylated by ABL1 in the nucleus
  • cell & other
    REGULATION
    inhibited by emerin
    Other regulated by tyrosine phosphorylation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS