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FLASH GENE
Symbol YPEL5 contributors: mct - updated : 01-04-2015
HGNC name yippee-like 5 (Drosophila)
HGNC id 18329
Location 2p23.2      Physical location : 30.369.749 - 30.383.398
Synonym name protein yippee-like 5
Synonym symbol(s) CGI-127
DNA
TYPE functioning gene
STRUCTURE 13.65 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2578 13.8 121 - 2010 20580816
4 - 2342 13.8 121 - 2010 20580816
3 - 2281 13.8 121 - 2010 20580816
4 - 2639 13.8 121 - 2010 20580816
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   predominantly
Reproductivefemale systemplacenta  highly
 male systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Ypel5
ortholog to drosophila Yippee
Homologene
FAMILY
  • YPEL (Yippee like) gene family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • in centrosome and nucleus during interphase and at the mitotic spindle during mitosis
  • at interphase, it was located in the nucleus and centrosome, then it changed location sequentially to spindle poles, mitotic spindle, and spindle midzone during mitosis, and finally transferred to midbody at cytokinesis
  • basic FUNCTION
  • DNA-directed RNA polymerase activity
  • possess a closely related function in the cell division cycle
  • involved in a certain cell division-related function, and in the cell cycle progression
  • seems to be involved in the cell cycle progression
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to two distinct proteins RanBP9 (Ran binding protein in the microtubule organizing center) and RanBP10
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    YPEL5/PPP1CB in Chronic lymphocytic leukemia (CLL), with N-terminal truncation caused by YPEL5/PPP1CB fusion decreasing the phosphatase activity of PPP1CB enzyme
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS