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FLASH GENE
Symbol YIPF6 contributors: mct - updated : 22-03-2016
HGNC name protein YIPF6
HGNC id 28304
Location Xq12      Physical location : 67.718.623 - 67.757.119
Synonym name
  • Yip1 domain family, member 6
  • Synonym symbol(s) FINGER6
    DNA
    TYPE functioning gene
    STRUCTURE 73.96 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 6282 - 236 - 2000 11256614
    6 - 6153 - 193 - 2000 11256614
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a long soluble N-terminal region, which is orientated towards the cytosol, followed by
  • 5 closely stacked transmembrane domains,
  • a C terminus, orientated towards the lumen of the Golgi
  • HOMOLOGY
    Homologene
    FAMILY Yip1 family
    CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • tissue- and organ-specific function in the maintenance of intestinal homeostasis
  • involved in ER to Golgi membrane transport
  • role for this family of proteins in regulating membrane dynamics in the endomembrane system
  • YIPF1, YIPF2, and YIPF6 play a significant role in supporting normal glycan synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IER3IP1, PPIB, EMC7, SPINT2, C14orf1/PEBP28, TMEM147, YIPF6, and KRTCAP2 interacting with SLC41A1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Mice with a null mutation in Yipf6 are hypersensitive to dextran sulfate sodium (DSS) induced colitis and develop spontaneous intestinal inflammation