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FLASH GENE
Symbol YIPF5 contributors: mct - updated : 08-07-2020
HGNC name Yip1 domain family, member 5
HGNC id 24877
Location 5q31.3      Physical location : 143.537.730 - 143.550.278
Synonym name
  • golgi membrane protein SB140
  • five-pass transmembrane protein localizing in the Golgi apparatus and
  • the endoplasmic reticulum 5
  • YPT-interacting protein 1 A
  • smooth muscle cell-associated protein 5
  • Synonym symbol(s) SB140, SMAP5, YIP1A, SMAP-5, FinGER5, DKFZp313L2216
    DNA
    TYPE functioning gene
    STRUCTURE 12.49 kb     6 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure proximal 5'-flanking region of the gene lacks a TATA box and is highly GC rich
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3395 - 257 - -
    5 - 3275 - 203 - -
    6 - 3144 - 257 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     pharynx   highly
    Nervousnerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularsmoothvessel highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a long soluble N-terminal region, which is orientated towards the cytosol, followed by
  • 5 closely stacked transmembrane domains,
  • a C terminus, orientated towards the lumen of the Golgi
  • HOMOLOGY
    interspecies homolog to yeast Yip1p
    Homologene
    FAMILY small Rab GTPase interacting factor protein family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    text
  • highest level of expression was found in coronary smooth muscle cells
  • primarily localise to the Golgi complex, and part of cis-Golgi-localising YIPFs (YIPF3, YIPF4 and YIPF5)
  • basic FUNCTION
  • may play an important role in inflammation
  • role for this family of proteins in regulating membrane dynamics in the endomembrane system
  • YIPF5 is essential for DNA virus- or intracellular DNA-triggered production of type I IFNs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with YIF1A and determines its localization to the Golgi apparatus
  • ability of YIPF5 to bind its established binding partners may be uncoupled from its ability to control ER whorl formation
  • YIPF5 is a positive regulator of STING1 trafficking
  • cell & other
    REGULATION
    induced by by transforming growth factor beta1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS