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FLASH GENE
Symbol YIPF3 contributors: mct - updated : 07-07-2020
HGNC name Yip1 domain family, member 3
HGNC id 21023
Location 6p21.1      Physical location : 43.479.565 - 43.484.728
Synonym name
  • killer lineage protein 1
  • natural killer cell-specific antigen KLIP1
  • chromosome 6 open reading frame 109
  • YIP1 family member 3
  • protein YIPF3
  • Synonym symbol(s) KLIP1, C6orf109, DKFZp566C243, dJ337H4.3, FinGER3
    DNA
    TYPE functioning gene
    STRUCTURE 5.09 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1507 38 350 - 2017 28286305
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythroblast
    Blood/Hematopoieticmature hematopoietic
    Blood/HematopoieticNK cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text erythroblast, liver CD34+, spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a yip1 domain
  • four transmembrane alpha helices
  • a long soluble N-terminal region, which is orientated towards the cytosol, followed by
  • 5 closely stacked transmembrane domains,
  • a C terminus, orientated towards the lumen of the Golgi
  • HOMOLOGY
    interspecies homolog to rattus LOC301245
    Homologene
    FAMILY
  • YIP1 family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • membrane or cytoplasmic molecule
  • YIPF3 is synthesized in the ER as a N-glycosylated form (40 kDa), is then O-glycosylated in the Golgi apparatus to become a lower mobility form (46 kDa) and finally becomes a higher mobility form cleaved at its C-terminal luminal domain (36 kDa)
  • primarily localise to the Golgi complex, and part of cis-Golgi-localising YIPFs (YIPF3, YIPF4 and YIPF5)
  • basic FUNCTION
  • playing an important role during hematopoiesis
  • involvement of YIPF3, YIPF4 in the maintenance of the Golgi structure
  • role for this family of proteins in regulating membrane dynamics in the endomembrane system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS