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Symbol YIF1A contributors: mct - updated : 08-07-2020
HGNC name Yip1 interacting factor homolog A (S. cerevisiae)
HGNC id 16688
Location 11q13.2      Physical location : 66.052.051 - 66.056.638
Synonym name
  • putative Rab5-interacting protein
  • putative transmembrane protein 54TMp
  • Yip1p-interacting factor
  • Synonym symbol(s) 54TM, FinGER7, YIF1, YIF1P
    DNA
    TYPE functioning gene
    STRUCTURE 4.56 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1097 - 293 - 2013 23736259
    7 - 941 - 241 - 2013 23736259
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     mouth   highly
    Endocrinepancreas   highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • heavy metal resistance factor 1 (HRF1) domain
  • multiple transmembrane segments
  • HOMOLOGY
    interspecies ortholog to murine Yif1a
    Homologene
    FAMILY YIF1 family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in ER to Golgi vesicle-mediated transport
  • both VAPB and YIF1A are important for ER-to-Golgi transport and missorting of YIF1A may contribute to VAPB-associated motor neuron disease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with YPF5 (determines localization of YIF1A to the Golgi apparatus)
  • VAPB strongly affects the distribution of YIF1A and is required for intracellular membrane trafficking into dendrites and normal dendritic morphology
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS