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FLASH GENE
Symbol YBX2 contributors: mct - updated : 07-04-2021
HGNC name Y box binding protein 2
HGNC id 17948
Location 17p13.1      Physical location : 7.191.570 - 7.197.876
Synonym name
  • contrin
  • germ cell specific Y-box binding protein
  • epididymis secretory sperm binding protein
  • Synonym symbol(s) CSDA3, MGC45104, MSY2, CONTRIN, DBPC
    DNA
    TYPE functioning gene
    STRUCTURE 6.39 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1654 - 364 - 2017 28970281
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary    Homo sapiens
     male systemtestis    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a CSD (cold-shock) domain
  • conjugated PhosphoP
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Ybx2
    ortholog to xenopus FRGY2
    Homologene
    FAMILY
  • cold-shock domain (CSD) family
  • Y-box family of DNA-/RNA-binding proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in the regulation of the stability and/or translation of germ cell mRNAs
  • may mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay
  • represents one of a small number of germ-cell-specific genes whose deletion leads to the disruption of both spermatogenesis and oogenesis
  • functions as a co-activator of transcription in male germ cells and plays an important role in the translational repression and storage of both paternal and maternal mRNAs in spermatocytes, spermatids and oocytes
  • central role of YBX2 in regulating mRNA stability
  • YBX2 and KDM3A genes may play an important role in male infertility
  • is a novel regulator that controls BAT activation by regulating mRNA stability
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    text
  • spermatogenesis
  • translational attenuation
  • PATHWAY
    metabolism
    signaling
    a component
  • mRNP complex with PABPC1 and CSDA
  • phosphorylated during oocyte maturation and dephosphorylated following egg activation
  • INTERACTION
    DNA
  • Y-box consensus promoter element
  • RNA
  • full length mRNA with high affinity in a sequence-independent manner
  • short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity
  • maternal mRNAs (necessary for its cytoplasmic retention)
  • small molecule
    protein
  • BNC1 role in spermatogenesis by directly binding to BNC1 binding elements in the promoter regions of both YBX2 and PAPOLB and inducing transcription of these important spermatogenesis genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • potential cause of male factor infertility
  • Marker
  • can act as useful biomarker for predicting male infertility
  • Therapy target
    ANIMAL & CELL MODELS
  • in Msy2-null males, spermatogenesis is disrupted in post-meiotic germ cells with many misshapen and multinucleated spermatids