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FLASH GENE
Symbol YBX1 contributors: mct - updated : 08-11-2018
HGNC name Y-box binding protein 1
HGNC id 8014
Location 1p34.2      Physical location : 43.148.065 - 43.168.017
Synonym name
  • major histocompatibility complex, class II, Y box-binding protein I
  • nuclease sensitive element binding protein 1
  • enhancer factor I subunit A
  • CCAAT-binding transcription factor I subunit A
  • DNA-binding protein B
  • Synonym symbol(s) DBPB, YB1, NSEP1, CSDB, BP-8, CSDA2, NSEP-1, MDR-NF1, YB-1, MGC104858, MGC110976, MGC117250, EFI-A, CBF-A
    DNA
    TYPE functioning gene
    STRUCTURE 19.95 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1561 36 324 - 2009 19098458
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   predominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the Y-box sequence 5' - CTGATTGG - 3' in its cis-regulatory elements
  • a cold shock domain homologous to DBPA (CSDA)
  • four putative DNA-binding domains, 3 of which are rich in basic amino acids
  • two of these basic regions, basic-1 and basic-2, form the double-strand DNA-binding domain of the protein
  • an octapeptide single-strand DNA-binding motif that shares weak homology with the ribonucleoprotein consensus sequence of RNA-binding proteins
  • HOMOLOGY
    Homologene
    FAMILY
  • cold-shock domain (CSD) family
  • CATEGORY RNA associated , transcription factor , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    text
  • in response to stress, YBX1 moved to cytoplasmic stress granules, where it colocalized with MBNL1 and YBX1 was previously reported to be a component of stress granules
  • actively secreted
  • basic FUNCTION
  • core component of messenger ribonucleoprotein particles (mRNPs) in the cytoplasm
  • regulating the expression of HLA class II genes
  • cell cycle stage-specific transcription factor important for cell proliferation
  • functioning under the regulation of GATA factors in erythroid differentiation
  • multifunctional DNA/RNA-binding protein that regulates transcription and translation
  • has RNA-binding specificity
  • acting as a ligand for Notch-3 receptors and modulating receptor activation
  • acting as an extracellular mitogen
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to Y-box
    RNA
    small molecule
    protein
  • interacts directly with SMAD3 during TGFbeta signal inhibition by interferon gamma
  • interacting with MECP2
  • PPM1G interacting with YBX1, a spliceosome-associated factor, through its acidic domain
  • binding to HSPD1 in the cytoplasm
  • interacting with NEIL2 (not only interacts physically with NEIL2, but it also cooperates functionally by stimulating its base excision activity by 7-fold)
  • PABPC1L and YBX1 associate with STAU2-containing mRNPs through RNAs
  • APEX1 stably interacts with Y-box-binding protein 1 (YBX1), and acts as its coactivator for the expression of multidrug resistance gene ABCB1, thereby causing drug resistance
  • HACE1 is a specific E3 ligase that polyubiquitinates YBX1 through non-canonical K27 linked ubiquitin chains
  • TNPO1 mediates YBX1 nuclear translocation
  • HCP5 regulated MSH5 expression and Granulosa cells function through direct binding with YBX1 and modulating its subcellular localization
  • cell & other
    REGULATION
    Other regulated by GATA transcription factors
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS