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FLASH GENE

Symbol

YBX1

contributors: mct - updated : 08-11-2017

HGNC name	Y-box binding protein 1
HGNC id	8014

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p34.2      Physical location : 43.148.065 - 43.168.017
Synonym name	major histocompatibility complex, class II, Y box-binding protein I
	nuclease sensitive element binding protein 1
	enhancer factor I subunit A
	CCAAT-binding transcription factor I subunit A
	DNA-binding protein B
Synonym symbol(s)	DBPB, YB1, NSEP1, CSDB, BP-8, CSDA2, NSEP-1, MDR-NF1, YB-1, MGC104858, MGC110976, MGC117250, EFI-A, CBF-A

DNA

TYPE	functioning gene
STRUCTURE	19.95 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004559 8 - 1561 NP_004550 36 324 - 2009 19098458

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       predominantly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

pancreas

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	the Y-box sequence 5' - CTGATTGG - 3' in its cis-regulatory elements
	a cold shock domain homologous to DBPA (CSDA)
	four putative DNA-binding domains, 3 of which are rich in basic amino acids
	two of these basic regions, basic-1 and basic-2, form the double-strand DNA-binding domain of the protein
	an octapeptide single-strand DNA-binding motif that shares weak homology with the ribonucleoprotein consensus sequence of RNA-binding proteins

HOMOLOGY

Homologene

FAMILY

cold-shock domain (CSD) family

CATEGORY

RNA associated , transcription factor , signaling

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,granule
	intracellular,nucleus
text	in response to stress, YBX1 moved to cytoplasmic stress granules, where it colocalized with MBNL1 and YBX1 was previously reported to be a component of stress granules
	actively secreted

basic FUNCTION	core component of messenger ribonucleoprotein particles (mRNPs) in the cytoplasm
	regulating the expression of HLA class II genes
	cell cycle stage-specific transcription factor important for cell proliferation
	functioning under the regulation of GATA factors in erythroid differentiation
	multifunctional DNA/RNA-binding protein that regulates transcription and translation
	has RNA-binding specificity
	acting as a ligand for Notch-3 receptors and modulating receptor activation
	acting as an extracellular mitogen

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to Y-box

RNA

small molecule

protein	interacts directly with SMAD3 during TGFbeta signal inhibition by interferon gamma
	interacting with MECP2
	PPM1G interacting with YBX1, a spliceosome-associated factor, through its acidic domain
	binding to HSPD1 in the cytoplasm
	interacting with NEIL2 (not only interacts physically with NEIL2, but it also cooperates functionally by stimulating its base excision activity by 7-fold)
	PABPC1L and YBX1 associate with STAU2-containing mRNPs through RNAs
	APEX1 stably interacts with Y-box-binding protein 1 (YBX1), and acts as its coactivator for the expression of multidrug resistance gene ABCB1, thereby causing drug resistance
	HACE1 is a specific E3 ligase that polyubiquitinates YBX1 through non-canonical K27 linked ubiquitin chains

cell & other

REGULATION

Other

regulated by GATA transcription factors

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS