Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | XYLT2 | contributors: mct - updated : 01-07-2015 |
HGNC name | xylosyltransferase II |
HGNC id | 15517 |
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Corresponding disease |
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Location | 17q21.33 Physical location : 48.423.392 - 48.438.511 | ||
Synonym name | UDP-D-xylose proteoglycan core XT2 protein beta-D-xylosyltransferase | ||
Synonym symbol(s) | XT-2, XT2, PXYLT2, XT-II, xylT-II | ||
EC.number | 2.4.2.26 |
DNA |
TYPE | functioning gene |
STRUCTURE | 15.15 kb 11 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | restricted |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
|
mono polymer | monomer |
HOMOLOGY |
interspecies | homolog to rattus Xylt2 |
intraspecies | homolog to XYLT1 |
Homologene |
FAMILY | glycosyltransferase family |
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,cytoplasm,organelle,membrane | |
intracellular,cytoplasm,organelle,endoplasmic reticulum | |
intracellular,cytoplasm,organelle,Golgi |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism | carbohydrate |
signaling |
chondroitin sulfate and heparan sulfate synthesis, first step |
a component |
INTERACTION |
DNA |
RNA |
small molecule | cofactor, |
divalent cations |
protein |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | COOD |
Susceptibility |
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Variant & Polymorphism SNP , other | |
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |
Xylt2 | |
/ | |
mice develop normally, but develop liver biliary epithelial cysts, renal tubule dilation/cysts, and decreased renal function |