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FLASH GENE
Symbol XRN2 contributors: mct - updated : 16-09-2014
HGNC name 5'-3' exoribonuclease 2
HGNC id 12836
Location 20p11.2-p11.1      Physical location : 21.283.941 - 21.370.463
Synonym name Dhm1-like protein (mouse homolog)
Synonym symbol(s) XRN2A
EC.number 3.1.11.-
DNA
TYPE functioning gene
STRUCTURE 86.00 kb     30 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - D20S917 - D20S177 - D20S189 - D20S98 - D20S112 - D20S182 - D20S180 - XRN2 - D20S871 - cen
Authors Zhang (99)
Physical map
SLC24A3 20p13 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 LOC388790 20 LOC388790 RPL12L3 20p11.22 ribosomal protein L12-like 3 RIN2 20p11.22 Ras and Rab interactor 2 NAT5 20p11.22 N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae) CRNKL1 20q12 Crn, crooked neck-like 1 (Drosophila) C20orf26 20p11.23 chromosome 20 open reading frame 26 RPL17P1 20p11.2 ribosomal protein L17 pseudogene 1 INSM1 20p11.21 insulinoma-associated 1 KIAA1272 20p11.22 KIAA1272 protein MRPS11P1 20p11.22 KIAA1272 protein LOC388791 20 LOC388791 C20orf19 20pter-q11.23 chromosome 20 open reading frame 19 RPS15AP1 20p11.22 ribosomal protein S15a pseudogene 1 XRN2 20p11.2-p11.1 5'-3' exoribonuclease 2 LOC391233 20 similar to Homeobox protein Nkx-2.4 (Homeobox protein NKX2.4) (Homeobox protein NK-2 homolog D) GSTM3P 20p11.22 glutathione S-transferase M3 pseudogene NKX2-2 20p11.22 NK2 transcription factor related, locus 2 (Drosophila) LOC388792 20 LOC388792 PAX1 20p11.2 paired box gene 1 SLC25A6P1 20p11 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6, pseudogene 1 RPL41P1 20p11.23-p11.21 ribosomal protein L41, pseudogene 1 ST13P 20p11.22 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene C20orf56 20 chromosome 20 open reading frame 56 FOXA2 20p11 forkhead box A2 KRT18P3 Xq21 keratin 18 pseudogene 3 CYB5P4 20p11.2 cytochrome b-5 pseudogene 4 SSTR4 20p11.2 somatostatin receptor 4 THBD 20p11.2 thrombomodulin C1QR1 20pter-p12-3 complement component 1, q subcomponent, receptor 1 LOC200261 20p11.22 hypothetical protein LOC200261
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 3449 - 950 ubiquitous Li
- splicing 3271 - 907 mainly expressed in blood leukocyte tissue Li
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinesmall intestine   
 intestinelarge intestinecolon  
 mouth   highly
Lymphoid/Immunethymus    
Reproductivefemale systemplacenta   
 female systemovary   
 male systemtestis  highly
Respiratoryrespiratory tractlarynx  highly
 respiratory tracttrachea  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one CCHC-type zinc finger
HOMOLOGY
interspecies homolog to murine Xrn2
homolog to rattus LOC362229
homolog to S.cerevisiae Rat1
Homologene
FAMILY 5'-3' exonuclease family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • 5'-3' exoribonuclease activity
  • promotes transcription termination at co-transcriptional cleavage sites
  • may be involved in homologous recombination, RNA synthesis and RNA trafficking
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, recombination
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • SETX resolves RNA/DNA hybrids formed at transcriptional pause sites to promote XRN2-dependent termination (pMID: 21700224)
  • NKRF mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS