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FLASH GENE
Symbol XRN2 contributors: mct - updated : 16-09-2015
HGNC name 5'-3' exoribonuclease 2
HGNC id 12836
Location 20p11.2      Physical location : 21.283.941 - 21.370.463
Synonym name Dhm1-like protein (mouse homolog)
Synonym symbol(s) XRN2A
EC.number 3.1.11.-
DNA
TYPE functioning gene
STRUCTURE 86.00 kb     30 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - D20S917 - D20S177 - D20S189 - D20S98 - D20S112 - D20S182 - D20S180 - XRN2 - D20S871 - cen
Authors Zhang (99)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 3449 - 950 ubiquitous Li
- splicing 3271 - 907 mainly expressed in blood leukocyte tissue Li
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinesmall intestine   
 intestinelarge intestinecolon  
 mouth   highly
Lymphoid/Immunethymus    
Reproductivefemale systemplacenta   
 female systemovary   
 male systemtestis  highly
Respiratoryrespiratory tractlarynx  highly
 respiratory tracttrachea  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one CCHC-type zinc finger
HOMOLOGY
interspecies homolog to murine Xrn2
homolog to rattus LOC362229
homolog to S.cerevisiae Rat1
Homologene
FAMILY 5'-3' exonuclease family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • 5'-3' exoribonuclease activity
  • promotes transcription termination at co-transcriptional cleavage sites
  • may be involved in homologous recombination, RNA synthesis and RNA trafficking
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, recombination
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • SETX resolves RNA/DNA hybrids formed at transcriptional pause sites to promote XRN2-dependent termination (pMID: 21700224)
  • new function for DCPS requires the contribution of the 5prime-3prime exonuclease XRN2
  • NKRF mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS