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FLASH GENE
Symbol XRN1 contributors: mct - updated : 23-05-2019
HGNC name 5'-3' exoribonuclease 1
HGNC id 30654
Location 3q23      Physical location : 142.025.450 - 142.166.853
Synonym name
  • strand-exchange protein 1
  • Synonym symbol(s) SEP1, FLJ41903, DKFZp434P0721, DKFZp686B22225
    EC.number 3.1.11.1/3.1.13.-
    DNA
    TYPE functioning gene
    STRUCTURE 141.46 kb     42 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    42 - 10143 - 1706 - 2018 29100804
    41 - 10107 - 1694 - 2018 29100804
    12 - 2152 - 459 - 2018 29100804
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
     pancreas exocrine   moderately
     pharynx   moderately
    Endocrineadrenal gland   moderately
     thyroid   highly
    Lymphoid/Immunelymph node   moderately
     thymus   moderately
    Reproductivefemale systembreastmammary gland predominantly
    Urinarybladder   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Xrn1 (89pc)
    homolog to Pacman, the Drosophila homologue of XRN1
    Homologene
    FAMILY
  • 5'-3'exonuclease family
  • CATEGORY enzyme , regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in homologous recombination, meiosis, telomere maintenance, and microtubule assembly
  • acting as a microtubule-associated protein which interacts with cytoplasmic microtubules through beta-tubulin
  • acting as major 5'-3' exoribonuclease involved in mRNA decay
  • required for the 5'-3'processing of the G4 tetraplex-containing DNA and RNA substrates
  • is a key component in the 5'-3' RNA degradation pathway
  • involved in RNA interference and degradation of microRNAs as well as RNA turnover
  • role for XRN1 in decapping
  • the buffering is rapidly established when mRNA synthesis is impaired, but is delayed when mRNA degradation is impaired, apparently due to XRN1-dependent transcription repressor induction
  • is a cellular factor regulating dsRNA accumulation and dsRNA-responsive innate immune effectors
  • DIS3L2 and XRN1 affect important cellular processes such as proliferation and apoptosis
  • is a key enzyme in the control of Flavivirus and Hepatitis C viral infection also present an opportunity for the development of broad-spectrum antiviral treatments
  • is necessary for checkpoint activation upon telomere uncapping because it promotes the generation of single-stranded DNA
  • is necessary for checkpoint activation upon telomere uncapping because it promotes the generation of single-stranded DNA
  • may act as a tumor suppressor protein in osteogenic sarcoma
  • regulates gene expression in eukaryotes by coupling nuclear DNA transcription to cytosolic mRNA decay
  • XRN1-dependence for translation is linked to poor structural RNA contexts for translation initiation, is mediated by interactions with components of the translation initiation machinery and correlates with an XRN1-dependence for mRNA localization at the endoplasmic reticulum
  • CELLULAR PROCESS nucleotide, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the mRNA decay complex (LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CCRN4L, UPF1, UPF2, UPF3B)
  • INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
  • XRN1 directly interacts with EDC4 and ACE
  • DCPS in conjunction with XRN1 has the potential to regulate RNA stability in a transcript-selective manner in mammalian cells
  • cell & other
    REGULATION
    induced by GDNF
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    osteogenic sarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS