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FLASH GENE
Symbol XPO7 contributors: mct - updated : 23-05-2012
HGNC name exportin 7
HGNC id 14108
Location 8p21.3      Physical location : 21.777.179 - 21.864.095
Synonym name
  • RAN binding protein 16
  • late erythroblast 2
  • Synonym symbol(s) KIAA0745, RANBP16, LEB-2
    DNA
    TYPE functioning gene
    STRUCTURE 86.92 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC286114 8p21.3 hypothetical protein LOC286114 GFRA2 8p22-p21 GDNF family receptor alpha 2 DOK2 8p21.2 docking protein 2, 56kDa XPO7 8p21 exportin 7 NPM2 8p21.3 nucleophosmin/nucleoplasmin, 2 FGF17 8p21 fibroblast growth factor 17 EPB49 8p21.1 erythrocyte membrane protein band 4.9 (dematin) RAI16 8p21.2 retinoic acid induced 16 FLJ22494 8p21.3 hypothetical protein FLJ22494 HR 8p22-p21 hairless homolog (mouse) FLJ22246 8p21.3 hypothetical protein FLJ22246 LGI3 8p21.2 leucine-rich repeat LGI family, member 3 SFTPC 8p21.2 surfactant, pulmonary-associated protein C BMP1 8p21.2 bone morphogenetic protein 1 PHYHIP 8p21.2 phytanoyl-CoA hydroxylase interacting protein POLR3D 8q21 polymerase (RNA) III (DNA directed) polypeptide D, 44kDa PIWIL2 8p21.2 piwi-like 2 (Drosophila) SLC39A14 8p21.2 solute carrier family 39 (zinc transporter), member 14 PPP3CC 8p21.2 protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma) LOC389639 8 LOC389639 SCAM-1 8p21.2 vinexin beta (SH3-containing adaptor molecule-1) PDLIM2 8p21.2 PDZ and LIM domain 2 (mystique) DBC-1 8p22 p30 DBC protein BIN3 8p21.2 bridging integrator 3 FLJ14107 8p21.2 hypothetical protein FLJ14107 EGR3 8p23-p21 early growth response 3 MGC22776 8p21.2 hypothetical protein MGC22776
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4907 - 1088 - 2000 11024021
    28 - 4880 - 1087 - 2000 11024021
    - - 4836 - 1096 - 2000 11024021
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systemovary   
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    N terminal RanGTP binding motif
    HOMOLOGY
    intraspecies paralog to RANBP17
    Homologene
    FAMILY importin beta superfamily of nuclear transport receptors
    CATEGORY receptor nuclear , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope,pore
    text binding the nuclear pore complexes
    basic FUNCTION
  • preventing activation of RanGTPase by RanGAP
  • nuclear exportin, playing a role in spermatogenesis as well as terminal erythroid differentiation
  • XPO7-dependent nuclear export signals differ fundamentally from the leucine-rich, XPO1-dependent ones, because basic residues are critical for XPO7 recruitment
  • involved in trafficking molecules out of the nucleus
  • XPO7 and RANBP17 are novel regulators of TCF3 protein action
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly binding to a nucleoporin implicated in translocation of transport receptors
  • STRADA facilitates nuclear export of STK11 by serving as an adaptor between STK11 and exportins XPO1 and XPO7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS