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FLASH GENE
Symbol XPO6 contributors: mct - updated : 19-11-2011
HGNC name exportin 6
HGNC id 19733
Location 16p11.2      Physical location : 28.109.315 - 28.223.190
Synonym name
  • cDNA sequence,expressed in brain,84kDa
  • RAN binding protein 20
  • Synonym symbol(s) RANBP20, FLJ22519, KIAA0370, EXP6
    DNA
    TYPE functioning gene
    STRUCTURE 113.87 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TNT 16p12.2 TNT protein LOC124199 16p12.2 similar to translation Elongation FacTor (eft-4) FLJ13798 16p12.2 hypothetical protein FLJ13798 NSE1 2p25.1 NSE1 IL4R 16p12.11-11.2 interleukin 4 receptor IL21R 16p11 interleukin 21 receptor GTF3C1 16p12.1-p11.2 general transcription factor IIIC, polypeptide 1, alpha 220kDa KIAA0556 16p12.2-p12.1 KIAA0556 protein MGC18079 16p12.1 hypothetical protein MGC18079 XPO6 16p12 exportin 6 LOC390687 16 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC388228 16 similar to SH3-binding kinase LOC388229 16 similar to Group X secretory phospholipase A2 precursor (Phosphatidylcholine 2-acylhydrolase GX) (GX sPLA2) (sPLA2-X) EIF3S8 16p11.2 eukaryotic translation initiation factor 3, subunit 8, 110kDa LOC283890 16p12.1 similar to nuclear pore complex interacting protein LOC388230 16 similar to MGC9515 protein LOC388231 16 LOC388231 SULT1A1 16p12.1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 SULT1A2 16p12-p11.2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 LOC112869 16p12.1 hypothetical protein BC011981 P8 16p11.2 p8 protein (candidate of metastasis 1) IL27  interleukin 27 LOC388232 16 similar to apolipoprotein B48 receptor CLN3 16p12.1-p11.2 ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) LOC388233 16 similar to MGC9515 protein APOB48R 16p11 apolipoprotein B48 receptor LOC388234 16 similar to nuclear pore complex interacting protein LOC390688 16 similar to CDC37-like gene LOC388235 16 LOC388235 LOC388236 16 similar to MGC9515 protein A2LP 16p11 ataxin 2 related protein TUFM 16p11.2 Tu translation elongation factor, mitochondrial SH2B 16p12.1 Tu translation elongation factor, mitochondrial ATP2A1 16p12.1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 FRA 16p12.1 Fos-related antigen CD19 16p11.2 CD19 antigen FLJ14639 16p12.1 hypothetical protein FLJ14639
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 4422 - 1125 - 2003 14592989
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Nervousbrain    
     nerve   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion lymph, blood
    at STAGE
    physiological period fetal
    Text umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    an importin N-terminal domain
    HOMOLOGY
    Homologene
    FAMILY exportin family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • recruit cargo in the nucleoplasm in the presence of RAN-GTP and form ternary export complexes
  • mediates nuclear export of profilin-actin complexes
  • first example of a strictly developmentally regulated nuclear transport pathway
  • reduction of its activity leads to actin accumulation via failure of RANGTP restoration and NUTF2 sequestration in the nuclei of senescent cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other reduction of exportin 6 activity leads to actin accumulation, in nuclei that is a universal phenomenon of cellular senescence
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    significantly reduced in the replicative senescence
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS