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FLASH GENE
Symbol XPO5 contributors: - updated : 11-03-2006
HGNC name exportin 5
HGNC id 17675
Location 6p21.1      Physical location : 43.490.068 - 43.543.812
Synonym symbol(s) KIAA1291
DNA
TYPE functioning gene
STRUCTURE 53.00 kb     32 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Lymphoid/Immunelymph node   highly
Nervousbrain   moderately
Reproductivemale systemtestis  highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Xpo5
homolog to rattus LOC363194
Homologene
FAMILY karyopherin family
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • mediates transport of protein between the nuclear and cytoplasmic compartments
  • plays a role in the export of JAZ and ILF3 from the nucleus
  • exports eEF1A via tRNA
  • regulates the translocation of double-stranded RNA-binding domain (dsRBD) proteins to the cytoplasm
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds NUP214, NUP153
  • interacts with RAN-GTP
  • interacting with STAU2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS