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FLASH GENE
Symbol XPO4 contributors: npt/mct - updated : 23-08-2010
HGNC name exportin 4
HGNC id 17796
Location 13q12.11      Physical location : 21.351.468 - 21.476.913
Synonym symbol(s) FLJ13046, KIAA1721, Exp4
DNA
TYPE functioning gene
STRUCTURE 125.45 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC390377 13 similar to Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide alpha-2,6-sialyltransferase (NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase) (ST6GalNAc IV) (Sialyltransferase 7D) (Sialyltransfer ZNF237 13q11-q12 zinc finger protein 237 LOC387901 13 LOC387901 ZNF198 13q11-q12 zinc finger protein 198 LOC144845 13q12.11 hypothetical protein BC008631 GJA3 13q11 gap junction protein, alpha 3, 46kDa (connexin 46) LOC390378 13 similar to peptidylprolyl isomerase A GJB2 13q11-q12.1 gap junction protein, beta 2, 26kDa (connexin 26) GJB6 13q12.1 gap junction protein, beta 6 (connexin 30) CRYL1 13q11 crystallin, lambda 1 TG737 13q12.1 crystallin, lambda 1 IL17D 13q12.11 interleukin 17D LOC221143 13q12.11 hypothetical protein LOC221143 XPO4 13q11 exportin 4 LOC390379 13 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) LOC387902 13 similar to protein 40kD LATS2 13q11-q12 LATS, large tumor suppressor, homolog 2 (Drosophila) LOC338870 13q12.11 similar to ribosomal protein S12 LOC390380 13 similar to chromosome 9 open reading frame 12; 1,3,4,5,6-pentakisphosphate 2-kinase SAP18 13q12.11 sin3-associated polypeptide, 18kDa C13orf3 13q11 chromosome 13 open reading frame 3 MRP63 13p11.1-q11 mitochondrial ribosomal protein 63 LOC387903 13 LOC387903 ESTRRA 13q12.11 estrogen-related receptor alpha pseudogene LOC387904 13 similar to hypothetical protein GPRK6P 13pter-q21 G protein-coupled receptor kinase 6 pseudogene LOC387905 13 LOC387905 FLJ25952 13q12.11 hypothetical protein FLJ25952 LOC387906 13 similar to RIKEN cDNA 5033406L14 LOC390382 13 similar to histone 1, H2bc; H2B histone family, member S FLJ34588 13q12.11 Smhs2 homolog (rat) LOC387907 13 similar to bA271B5.1 (similar to ribosomal protein S7) FGF9 13q11-q12 fibroblast growth factor 9 (glia-activating factor)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 9902 - 1151 - Lipowsky (2000)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • exportin family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • mediates nuclear export of eIF-5A (Lipowsky 2000)
  • acts as a bona fide nuclear import receptor for SOX2 and SRY (Gontan 2009)
  • nuclear transport receptor carrying distinct cargoes into different directions, and mediating a novel nuclear import pathway for Sox family transcription factors (Gontan 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex EIF5A-Xpo4-RanGTP
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to GTP-bound form of Ran
  • interacting with EIF5A2, its substrate (EIF5A2 is amplified in tumors, and required for proliferation of XPO4-deficient tumor cells) (Zender 2008)
  • interacting with SMAD3 (binds a conserved peptide sequence in the MH2 domain of SMAD3 in a Ran-dependent manner and is sufficient for carrying the nuclear export of SMAD3 in cooperation with RAN) (Kurisaki 2006)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS