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FLASH GENE
Symbol XPNPEP2 contributors: mct - updated : 26-02-2011
HGNC name X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
HGNC id 12823
Location Xq26.1      Physical location : 128.872.945 - 128.903.525
Synonym name
  • aminoacylproline aminopeptidase
  • membrane-bound aminopeptidase P
  • xaa-Pro aminopeptidase 2
    • Synonym symbol(s) APP2, mAmP
    EC.number 3.4.11.9
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 30.58 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3333 71 674 - 2005 16175507
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  highly
     liver   highly
    Reproductivefemale systemplacenta  highly
    Respiratorylung   highly
    Urinarykidney   predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • protein shuttle
  • five divalent metal ligand sites
    • HOMOLOGY
    interspecies homolog to E.coli methionine amidopeptidase
    Homologene
    FAMILY
  • pita-bread fold protein family
  • peptidase M24B family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text cell surface membrane-bound
    basic FUNCTION
  • X-prolyl aminopeptidase, hydrolyzing N terminal imido (Xaa-Pro) bonds
  • presumably functions in the degradation of both dietary and filtered peptides by intestinal and renal epithelial brush border membranes, respectively
  • may have unrecognized roles in cell trafficking and in immune function
  • coinactivating vasodilatator bradykinin in the lung with angiotensin converting enzyme
  • can hydrolyze bradykinin containing a penultimate proline residue
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • co-inactivating vasodilator bradykimin in the lung with angiotensin converting enzyme
    • cell & other membrane bound
    REGULATION
    inhibited by
    specific inhibitor, apstatin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to angioedema induced by angiotensin I-converting enzyme inhibitors
    Variant & Polymorphism SNP C2399A associated with angioedema induced by angiotensin I-converting enzyme inhibitors
    Candidate gene for premature ovarian failure
    Marker
    Therapy target chemical inhibitors for XPNPEP2 may result in novel therapeutic approaches for the prevention of myocardial infarction
    ANIMAL & CELL MODELS