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FLASH GENE
Symbol XKR6 contributors: mct/npt - updated : 03-09-2009
HGNC name XK, Kell blood group complex subunit-related family, member 6
HGNC id 27806
Location 8p23.1      Physical location : 10.753.656 - 11.058.875
Synonym name
  • chromosome 8 open reading frame 7
  • chromosome 8 open reading frame 21
  • X Kell blood group precursor-related family, member 6
  • XK-related protein 6
  • chromosome 8 open reading frame 5
    • Synonym symbol(s) C8orf7, C8orf21, XRG6, C8orf5
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    text an intronic microRNA gene, mir-598, which is highly expressed in peripheral blood mononuclear cells, especially activated B cells (Harley 2009)
    STRUCTURE 305.22 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3761 71 641 - Appel (2002)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to C.elegans F21A10.1
    Homologene
    FAMILY
  • PDZ conserved binding motif-containing proteins family
  • XK family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • implicated in regulating the timing of apoptosis (Harley 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to systemic lupus erythematosus (SLE)
    Variant & Polymorphism other polymorphisms implicated in SLE risk (Harley 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS