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FLASH GENE
Symbol XCL1 contributors: mct/npt - updated : 07-01-2013
HGNC name chemokine (C motif) ligand 1
HGNC id 10645
Location 1q24.2      Physical location : 168.545.855 - 168.551.315
Synonym name
  • small inducible cytokine subfamily C, member 1 (lymphotactin)
  • lymphotactin
  • XC chemokine ligand 1
  • single C motif-1
  • activation-induced, T cell-derived, and chemokine-related
  • Synonym symbol(s) LTCT, SCM1, SCYC1, SCM1B, LTN, ATAC, SCM-1a, LPTN
    DNA
    TYPE functioning gene
    STRUCTURE 5.60 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC391130 1 similar to ribosomal protein S17 POU2F1 1q22-q23 POU domain, class 2, transcription factor 1 CD3Z 1q22-q23 CD3Z antigen, zeta polypeptide (TiT3 complex) SRD5BP1 1q23-q25 steroid-5-beta-reductase, beta polypeptide pseudogene 1 CREG 1q24 cellular repressor of E1A-stimulated genes MGC21854 1q22-q24 hypothetical protein MGC21854 MPZL1 1q23.2 myelin protein zero-like 1 FLJ21047 1q23.3 hypothetical protein FLJ21047 SAC DKFZP564B167 1q24 DKFZP564B167 protein PC326 1q23.3 PC326 protein GCSH 16q24 glycine cleavage system protein H (aminomethyl carrier) GPR161 1q23.3 G protein-coupled receptor 161 MGC3794 1q23.2 putative MAPK activating protein RPL34P1 1q23-q24 ribosomal protein L34 pseudogene 1 LOC375035 1q23.3 hypothetical protein LOC375035 MGC12538 1q23.3 hypothetical protein MGC12538 TBX19 1q23-q24 T-box 19 LOC391131 1 similar to glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 XCL2 1q23-q25 chemokine (C motif) ligand 2 XCL1 1q23 chemokine (C motif) ligand 1 DPT 1q12-q23 dermatopontin MGC4473 1q23.3 hypothetical protein MGC4473 LOC391132 1 similar to ribosomal protein L29 ATP1B1 1q23.2-q23.3 ATPase, Na+/K+ transporting, beta 1 polypeptide NME7 1q24 non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) BLZF1 1q24-q25 basic leucine zipper nuclear factor 1 (JEM-1) LOC57821 1q24 hypothetical protein LOC57821 SLC19A2 1q23.2-q23.3 solute carrier family 19 (thiamine transporter), member 2 F5 1q23.2-q23.3 coagulation factor V (proaccelerin, labile factor) SELP 1q23.2-q41.2 selectin P (granule membrane protein 140kDa, antigen CD62) SELL 1q23.2-q23.3 selectin L (lymphocyte adhesion molecule 1) SELE 1q23.2-q23.1 selectin E (endothelial adhesion molecule 1) MGC9084 1q23.3 hypothetical protein MGC9084 FLJ10706 1q23.3 hypothetical protein FLJ10706 PACE-1 1q23.3 ezrin-binding partner PACE-1 KIFAP3 1q23.2 kinesin-associated protein 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1367 12.5 114 - 1996 8849694
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly Homo sapiens
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneepithelial cell Homo sapiens
    Lymphoid/Immunelymphocyte
    Lymphoid/Immunenatural killer Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • small inducible cytokine, retaining only two of the four cysteine of CC and CXC subfamilies
  • HOMOLOGY
    intraspecies homolog to XCL2
    Homologene
    FAMILY
  • small inducible cytokine, subfamily C
  • intercrine gamma family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • has chemotactic activity for lymphocytes but not for monocytes or neutrophils
  • utilizes highly specific glycosaminoglycan-binding sites that represent potential targets for drug development
  • XCL1 may support vascular inflammation by induction of release of interleukin 8 in polymorphonuclear neutrophils
  • regulate independent and distinct steps during transcription initiation and elongation
  • C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses
  • XCL1 and XCR1 are constitutively expressed in the thymus and regulate the thymic establishment of self-tolerance and the generation of regulatory T cells
  • role of XCR1 and its Ligand XCL1 in Antigen Cross-Presentation byhuman dendritic cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • XCL1-XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic immune response
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with XCR1 (XC chemokine receptor-1)
  • AIRE-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
  • cell & other
    REGULATION
    induced by in peripheral blood mononuclear cells by mitogenic stimulation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in CD4+ and CD8+ T cells in Wegener granulomatosis
    constitutional     --low  
    associated with the suboptimal regulatory function of Treg in allergic asthma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • thymocytes from XCL1-deficient mice elicit dacryoadenitis in nude mice
  • Xcl1-deficient mice are defective in the medullary accumulation of thymic dendritic cells and the thymic generation of naturally occurring regulatory T cells (nT reg cells)