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FLASH GENE
Symbol XAGE1A contributors: npt - updated : 06-01-2006
HGNC name X antigen family, member 1A
HGNC id 4111
Location Xp11.22      Physical location : 52.238.809 - 52.546.197
Synonym name
  • G antigen, family D, 2
  • X antigen family, member 1
  • cancer/testis antigen 12.1
  • protein XAGE-1
  • Synonym symbol(s) GGD2, GAGED2, XAGE1, CT12.1a
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 5.14 kb     4 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure expression regulated by methylation of the CpG island in the gene promoter, in normal and cancerous tissues
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 splicing 622 - 81 - Zendman (2002)
    also called variant a or XAGE-1a
    3 - 485 - 69 - Zendman (2002)
    also called variant d or XAGE-1d
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    Respiratorylung    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymhoid/Immunelymphocyte
    cell lineage
    cell lines Ewing's cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a nuclear localization signal (NLS)
  • a potential transmembrane domain in the N terminus
  • HOMOLOGY
    intraspecies homolog to GAGE/PAGE protein
    Homologene
    FAMILY
  • GAGE family
  • XAGE subfamily
  • CATEGORY antigen , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • cancer/testis-associated gene playing a role in the carcinogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Ewing sarcoma
    tumoral     --over  
    in alveolar rhabdomyo-sarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS