Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol XAF1 contributors: mct - updated : 27-10-2007
Location 17p13.2      Physical location : 6.659.155 - 6.678.962
Genatlas name XIAP associated factor-1
Synonym name X-linked inhibitor of apoptosis (XIAP)-associated factor 1
Synonym symbol(s) HSXIAPAF1, XIAPAF1, BIRC4BP
DNA
TYPE functioning gene
STRUCTURE 19.00 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
Map cen - D17S926 - D17S2169 - D17S2167 - [D17S1828 - D17S1832 ] - D17S796 - D17S1881 - D17S786 - cen
Authors Fong (00)
Text [XIAPAF1 ]
regionally located telomeric to TP53
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3581 - 282 widely, low expression in any cancer cell lines Kempkensteffen (2007)
lacks exon 3
- - 3638 - 301 widely, not expressed in cancer cell lines Kempkensteffen (2007)
- - - 6000 - - widely, not expressed in cancer cell lines -
- - - 7000 - - widely, not expressed in cancer cell lines -
- - - - 164 . in a variety of cancer cell lines and also in normal tissues Yin (2006)
  • containing a cryptic exon (exon 4b) that into the mRNA introduces an in-frame stop codon
  • lacking the C-terminal domain of the previously described XAF1(A), but containing a unique 24 AA carboxy terminus
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
    Lymphoid/Immunespleen   highly
    Reproductivefemale systemuterus   
     male systemtestis   
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six zinc finger motifs at its N-terminus
  • TRAF type zinc finger, required for self-association or interaction with other proteins
  • C-terminal portion critical for its pro-apoptotic function
  • HOMOLOGY
    intraspecies homolog to FLN29,TRAF3
    Homologene
    FAMILY
    CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulation of apoptosis (loss of XAF1 important for malignant cell survival)
  • antagonizing the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells
  • plays a critical role in interferon-induced sensitization to TNF-related apoptosis-inducing ligand
  • mediates apoptosis induced by the ERK1/2 pathway in colon cancer (Yu 2007)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with XIAP to regulate motoneuron resistance to apoptotic cell death
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibiting the function of CASP3, CASP7 and CASP9 key effector proteases of apoptosis
  • binds to XIAP and blocks its anti-apoptotic activity
  • cell & other
    REGULATION
    activated by IFNA,IFNB
    Other induced expression in cancer cell lines, with high levels of XIAP
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    low expressed by aberrant promoter methylation in gastric adenocarcinoma in progression
    tumoral        
    by hypermethylation in prostate, kidney and bladder carcinoma, in malignant progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS