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FLASH GENE
Symbol XAB2 contributors: KTN/npt/pgu - updated : 09-07-2008
HGNC name XPA binding protein 2
HGNC id 14089
Location 19p13.2      Physical location : 7.684.411 - 7.694.439
Synonym name
  • crn-related protein kim1
  • Pre-mRNA-splicing factor SYF1
  • SYF1 homolog, RNA splicing factor (S. cerevisiae)
  • Synonym symbol(s) HCNP, HCRN, SYF1, NTC90, KIAA1177, DKFZp762C1015
    DNA
    TYPE functioning gene
    STRUCTURE 10.00 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC284428 19p13.3 similar to methyl-CpG binding domain protein 3-like 2 MBD3L2 19p13.3 methyl-CpG binding domain protein 3-like 2 LOC388498 19 similar to methyl-CpG binding domain protein 3-like 2 MGC4054 19p13.3 hypothetical protein MGC4054 INSR 19p13.3-p13.2 insulin receptor P114-RHO-GEF 19p13.3 insulin receptor PEX11G 19p13.2 peroxisomal biogenesis factor 11 gamma FLJ35784 19p13.3 FLJ35784 protein ZNF358 19p13.3 zinc finger protein 358 MCOLN1 19p13.3-13.2 mucolipin 1 NTE 19p13.3-p13.2 mucolipin 1 KIAA1543 19p13.3-p13.2 mucolipin 1 XAB2 19p13.3 XPA binding protein 2 MGC41903 STXBP2 19p13.3-p13.2 syntaxin binding protein 2 RETN 19p13.3 resistin LOC199675 19p13.3 hypothetical protein LOC199675 TRAPPC5 19p13.3 trafficking protein particle complex 5 FCER2 19p13.3 Fc fragment of IgE, low affinity II, receptor for (CD23A) UNQ431 19p13.3 DTTR431 CD209 19p13 CD209 antigen CD209L 19p13.3 CD209 antigen-like LOC390879 19 similar to DTTR431 LOC115704 19p13.3 similar to ecotropic viral integration site 5; Neuroblastoma stage 4S gene LOC388499 19 similar to lysophospholipase II; acyl-protein thioesterase FLJ23420 19p13.3 hypothetical protein FLJ23420 MAP2K7 19p13.2 mitogen-activated protein kinase kinase 7 LOC388500 19 LOC388500 SNAPC2 19q13.3-p13.2 small nuclear RNA activating complex, polypeptide 2, 45kDa TIMM44 19p13.3-p13.2 translocase of inner mitochondrial membrane 44 homolog (yeast) ELAVL1 19p13.2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) CCL25 19p13.2 chemokine (C-C motif) ligand 25 FBN3 19p13 fibrillin 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 2682 99 855 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   moderately
    Endocrineadrenal gland    
     thyroid   predominantly
    Lymphoid/Immunelymph node   moderately
     spleen    
    Nervousbrain    
    Reproductivefemale systemplacenta  moderately
     female systemovary  moderately
     male systemprostate  moderately
    Respiratorylung    
    Skin/Tegumentskin   moderately
    Visualeye   moderately
    cell lineage
    cell lines
    fluid/secretion highly in blood and lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • foureen HAT repeats
  • ten tetratricopeptide repeats (TPR)
  • HOMOLOGY
    interspecies homolog to dog XAB2 (98.8 pc)
    homolog to rattus Xab2 (99 pc)
    homolog to murine Xab2 (98.8 pc)
    Homologene
    FAMILY
  • crooked-neck family
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text spliceosome
    basic FUNCTION
  • involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, repair, nucleotide excision repair
    nucleotide, transcription, regulation
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS development
    text
  • mRNA processing
  • blastocyst development
  • PATHWAY
    metabolism
    signaling
    a component
  • associated with RNA polymerase II
  • INTERACTION
    DNA
    RNA
    small molecule
    protein binding to XPA, CSA, CSB, POLR2
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS