basic FUNCTION
| transcriptional corepressor for WT1, that shuttles into the nucleus after podocyte injury, translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype |
|
involved in kidney and neural crest development |
|
able to inhibit canonical Wnt signalling in mammalian cells |
|
adaptor protein that exhibit the potential to communicate cell adhesive events with nuclear responses to remodel epithelia |
|
having role as negative regulatorof the Hippo signaling pathway |
|
required for microRNA-mediated gene silencing |
|
coordinates cell adhesion changes and transcriptional responses to regulate podocyte phenotypic plasticity |
|
ASXL2 and WTIP are involved in regulation of retinoic acid signaling during heart development |