Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol WTIP contributors: mct - updated : 27-08-2015
HGNC name Wilms tumor 1 interacting protein
HGNC id 20964
Location 19q13.11      Physical location : 34.972.879 - 34.992.084
Synonym name WT1-interacting protein
DNA
TYPE functioning gene
STRUCTURE 19.21 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2204 45.1 430 - 2004 14736876
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Urinarypodocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
Text expression in developing renal glomeruli
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a proline-rich, pre-LIM region with a nuclear export signal
  • three C-terminal LIM protein-protein interaction domains
  • HOMOLOGY
    Homologene
    FAMILY
  • Ajuba LIM proteins family
  • zyxin/ajuba family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,nucleus
    text
  • shuttles into the nucleus after podocyte injury, providing a mechanism whereby changes in slit diaphragm structure modulate gene expression
  • basic FUNCTION
  • transcriptional corepressor for WT1, that shuttles into the nucleus after podocyte injury, translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype
  • involved in kidney and neural crest development
  • able to inhibit canonical Wnt signalling in mammalian cells
  • adaptor protein that exhibit the potential to communicate cell adhesive events with nuclear responses to remodel epithelia
  • having role as negative regulatorof the Hippo signaling pathway
  • required for microRNA-mediated gene silencing
  • coordinates cell adhesion changes and transcriptional responses to regulate podocyte phenotypic plasticity
  • ASXL2 and WTIP are involved in regulation of retinoic acid signaling during heart development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • intracellular interaction partner of ROR2
  • directly interacted with Rho guanine nucleotide exchange factor (GEF) 12 (ARHGEF12), a RhoA-specific GEF enriched in the glomerulus
  • dendrin binds to WTIP and GADD45A (WTIP and GADD45A mediate gene transcription in the nucleus, suggesting that dendrin may have similar functions in podocytes
  • is a ASXL2-binding partner
  • NCK1 integrates NPHS1 with the Hippo kinase cascade through association with the adaptor protein WTIP
  • WTIP interacts with BRCA2 and might be responsible for BRCA2 centrosome localization in cervical cancer cell
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS