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FLASH GENE
Symbol WTAP contributors: mct - updated : 13-11-2019
HGNC name Wilms tumor 1 associated protein
HGNC id 16846
Location 6q25.3      Physical location : 160.148.151 - 160.177.349
Synonym name
  • PNAS-132
  • putative pre-mRNA splicing regulator female-lethal(2D)
  • female-lethal(2)D homolog
  • WT1-associated protein
  • Synonym symbol(s) KIAA0105, MGC3925, DKFZp686F20131, PNAS-132, hFL(2)D, MUM2
    DNA
    TYPE functioning gene
    STRUCTURE 29.62 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TCTEL1 6q25.2-q25.3 t-complex-associated-testis-expressed 1-like 1 SYTL3 6q25.3 synaptotagmin-like 3 VIL2 6q25-q26 villin 2 (ezrin) LOC389439 6 LOC389439 LOC202459 6q25.3 similar to RIKEN cDNA 2310008M10 LOC389440 6 LOC389440 LOC346064 6q25.3 similar to SNARE protein Ykt6; YKT6, S. cerevisiae, homolog of RSHL2 6q25.3 radial spokehead-like 2 TAGAP 6q25.3 T-cell activation GTPase activating protein LOC389441 6 LOC389441 LOC389442 6 LOC389442 LOC389443 6 LOC389443 LOC389444 6 similar to frazzled CG8581-PA FNDC1 6q25 fibronectin type III domain containing 1 LOC389445 6 similar to 60S ribosomal protein L21 SOD2 6q25.2 superoxide dismutase 2, mitochondrial WTAP 6q25-q27 Wilms tumor 1 associated protein ACAT2 6q25.3-q26 acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) TCP1 6q25.1-q25.2 t-complex 1 MRPL18 6q25.3 mitochondrial ribosomal protein L18 PNLDC1 6q25.3 poly(A)-specific ribonuclease (PARN)-like domain containing 1 MAS1 6q25.3-q26 MAS1 oncogene IGF2R 6q26-q27 insulin-like growth factor 2 receptor SLC22A1 6q27 solute carrier family 22 (organic cation transporter), member 1 SLC22A2 6q26-q27 solute carrier family 22 (organic cation transporter), member 2 SLC22A3 6q26-q27 solute carrier family 22 (extraneuronal monoamine transporter), member 3 APOAL 6q26-q27 apolipoprotein A-like LPA 6q26-q27 lipoprotein, Lp(a) PLG 6q26 plasminogen LOC389446 6 similar to apolipoprotein(a) (EC 3.4.21.-) - rhesus macaque (fragment) LOC389447 6 LOC389447
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2143 - 396 - 2018 29348140
    6 - 1644 - 151 - 2018 29348140
    7 - 1636 - 170 - 2018 29348140
    6 - 1856 - 151 - 2018 29348140
    8 - 2105 - 396 - 2018 29348140
    7 - 1488 - 170 - 2018 29348140
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Endocrineparathyroid   highly
    Nervousnervecranial nerve  highly
    Reproductivemale systemprostate  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    ReproductiveSertoli cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Wtap
    homolog to drosophila female-lethal-2-D
    Homologene
    FAMILY
  • FL(2)D family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • partially colocalizing with splicing factor
  • METTL3/METTL14 is found in the nucleus where it is localized to nuclear speckles and the splicing regulator WTAP is required for this distinct nuclear localization pattern
  • basic FUNCTION
  • involved in the morphogenesis of the genitourinaty tract
  • essential factor for the stabilization of cyclin A2 mRNA, thereby regulating G2/M cell-cycle transition
  • WTAP complex is a novel component of the RNA processing machinery, implying an important role in both posttranscriptional control and cell cycle regulation
  • WTAP may function as a regulatory subunit in the m6A methyltransferase complex and play a critical role in epitranscriptomic regulation of RNA metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text embryonal development, sperm production
    PATHWAY
    metabolism
    signaling
    a component
  • RNA methyltransferase complex of WTAP, METTL3, and METTL14 regulates mitotic clonal expansion in adipogenesis
  • trimer N-6-methyltransferase METTL3-METTL14-WTAP complex is linked to such critical biological processes as cell differentiation, proliferation, and death
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WT1 (C terminus)
  • activity of epidermal growth factor receptor can be regulated by WTAP
  • WTAP interacts with METTL3 and METTL14, and is required for their localization into nuclear speckles enriched with pre-mRNA processing factors and for catalytic activity of the m6A methyltransferase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly up-regulated in hepatocellular carcinoma significantly up-regulated and promotes liver cancer development
    tumoral     --over  
    in glioblastoma which is regarded as a grade IV astrocytoma
    tumoral     --over  
    in glioblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a novel prognostic marker in glioma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    WTAP is a potential therapeutic target of HCC treatment
    ANIMAL & CELL MODELS