| basic FUNCTION
| multifunctional nuclear protein possessing 3'-5' exonuclease and ATP-dependent helicase activities |
|
contributes to the maintenance of genome integrity through its involvement in DNA repair |
|
plays a direct role in the repair of methylation-induced DNA damage |
|
involved in genome stability maintenance and in preventing aberrant deleterious recombinogenic pathways when replication perturbed by DNA damage, alternate DNA structure or impaired DNA synthesis |
|
involved in 3' to 5' DNA ATP dependent, unwinding function, in RNA polymerase II activation in DNA repair replication foci formation through interaction with POLDs |
|
involved with PRKDC in non-homologous end joining |
|
involved in telomere dynamics and maintenance |
|
facilitating FEN1 cleavage of DNA replication/repair intermediates, important for the role of WRN in the maintenance of genomic stability |
|
possessing a 3' to 5' exonuclease activity in addition to the 3' to 5' helicase activity characteristic of other RecQ proteins |
|
required for genomic stability and avoidance of cancer |
|
having ATPase, helicase, exonuclease and single-stranded DNA annealing activities |
|
may protect the genome from the lethal, mutagenic and carcinogenic effects of widely diverse DNA damage arising from endogenous processes and environmental agents |
|
playing roles in dissociating telomeric structures in telomerase-deficient cells |
|
playing a role in processing of telomeric DNA and subsequent activation of DNA damage responses |
|
having an helicase activity necessary to prevent dramatic telomere loss during DNA replication |
|
playing a role in homology-dependent recombination repair (HDR) that can be used to repair DNA damage while suppressing gene loss or rearrangement |
|
also has an important role in the maintenance of telomere length and the suppression of telomere sister-chromatid exchanges |
|
functioning in dissociating alternative DNA structures during recombination and/or replication at telomeric ends |
|
plays a significant role in oxidative DNA damage repair via an important association with NEIL1 |
|
undergoing metal-catalyzed oxidation in the presence of iron (iron-mediated oxidation of WRN likely results in the accumulation of a catalytically inactive form of the protein, which may contribute to age-related phenotypes, and oxidatively modified WRN may have deleterious effects on DNA repair and telomere maintenance pathways) |
|
might regress replication forks as part of a genome maintenance pathway |
|
may prevent the stalling and collapse of replication forks that encounter damaged DNA |
|
required to avoid accumulation of double-strand breaks and fork collapse after replication perturbation |
|
contributes to the maintenance of genomic integrity through its involvement in DNA repair, replication and recombination |
|
participates in the same repair pathway as NEIL1  |
|
key regulator of fragile site stability |
|
stabilizes fragile sites acting in a common pathway with the ataxia telangiectasia and Rad3 related replication checkpoint (providing the first evidence of a crucial role for a helicase in protecting cells against chromosome breakage at normally occurring replication fork stalling sites) |
|
cooperation between both helicases WRN and DHX9, may serve to form and to dissolve Holliday junction-like intermediates of regressed replication forks |
|
may be playing a role in Okazaki fragment maturation |
|
cooperative functions for WRN and DHX9 at both migrating and stalled replication forks, where they seem to be involved in the removal of primer RNA-containing Okazaki fragments |
|
directly phosphorylated by ATR at multiple C-terminal S/TQ residues |
|
with POT1, are required for efficient chromosome segregation |
|
WRN and BLM are critical for maintaining genomic stability and thought to function in accurate resolution of replication blockage |
