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FLASH GENE
Symbol WNT7B contributors: mct - updated : 04-07-2018
HGNC name wingless-type MMTV integration site family, member 7B
HGNC id 12787
Location 22q13.31      Physical location : 46.316.247 - 46.373.008
Synonym name protein Wnt-7b
Synonym symbol(s) WN7B
DNA
TYPE functioning gene
STRUCTURE 56.77 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 3928 - 349 - 2001 11562755
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine   moderately
 stomach   predominantly
Nervousbrain    
Reproductivemale systemprostate  highly
Urinarybladder   highly
 kidneytubulecollecting duct highly
Visualeye   moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
Skeletonosteoblast
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text specific region of forebrain, kidney, limb ectoderm, lung
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cysteine rich domains
  • three N-linked glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (wg) segment polarity gene
    ortholog to murine Wnt7b
    intraspecies homolog to WNT7A
    Homologene
    FAMILY
  • WNT family
  • CATEGORY protooncogene , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • modulating cell fate and cell behavior during vertebrate development
  • playing a role in the development and progress of gastric, esophageal and pancreatic cancer
  • being a ligand for members of the frizzled family of seven transmembrane receptors
  • involved in a short-range paracrine signal required for WNT-pathway responses and programmed cell death in the vascular endothelial cells of the temporary hyaloid vessels of the developing eye
  • modulates several important signaling pathways in the lung
  • Wnt pathway ligand, produced by macrophages to stimulate repair and regeneration
  • stimulate epithelial responses during kidney development
  • key regulator of the tissue architecture that establishes a functional physiologically active mammalian kidney
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SHH during mammalian tooth development
  • RECK and GPR124 are part of the cell surface protein complex that transduces WNT7A- and WNT7B-specific signals in mammalian CNS endothelial cells (ECs) to promote angiogenesis and regulate the Blood-Brain Barrier
  • interplay of NDP and WNT7A/WNT7B signaling systems in blood-brain barrier and blood-retina barrier development and maintenance
  • cell & other
    REGULATION
    activated by all-trans retinoic acid in embryonal tumor
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast carcinoma and gastric cancer
    constitutional       gain of function
    abnormal upregulation in the levels of WNT2B and WNT7B in neural tube defects (NTDs)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    in mouse, Wnt7b-null lungs are markedly hypoplastic, yet display largely normal patterning and cell differentiation