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FLASH GENE
Symbol WNT6 contributors: mct - updated : 26-08-2016
HGNC name wingless-type MMTV integration site family, member 6
HGNC id 12785
Location 2q35      Physical location : 219.724.545 - 219.738.954
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
text clustered with WNT10A in head to tail manner with an interval of less than 7kb
STRUCTURE 14.41 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1700 37.2 365 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta moderatly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cysteine rich
  • two N-linked glycosylation sites
  • an N terminal signal peptide WNT core domain
  • an RGD motif
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (wg) segment polarity gene
    ortholog to murine Wnt6
    homolog to C.elegans t37e11c.a
    intraspecies homolog to WNT1
    Homologene
    FAMILY
  • WNT family
  • CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
    text associated with the extracellular matrix
    basic FUNCTION
  • involved in short-range signaling during embryonic patterning
  • playing a key role in carcinogenesis through activation of WNT-beta-catenin-TCF signaling pathway
  • ligand for members of the frizzled family of seven transmembrane receptors
  • WNT6, WNT10A and WNT10B inhibit adipogenesis and stimulate osteoblastogenesis through a CTNNB1-dependent mechanism
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer with WNT10A
    tumoral     --over  
    in cervical cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS