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FLASH GENE

Symbol

WNT6

contributors: mct - updated : 26-08-2016

HGNC name	wingless-type MMTV integration site family, member 6
HGNC id	12785

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q35      Physical location : 219.724.545 - 219.738.954

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
text	clustered with WNT10A in head to tail manner with an interval of less than 7kb
STRUCTURE	14.41 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed WNT6 4 - 1700 37.2 365 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta moderatly

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	cysteine rich
	two N-linked glycosylation sites
	an N terminal signal peptide WNT core domain
	an RGD motif

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to Drosophila wingless (wg) segment polarity gene
	ortholog to murine Wnt6
	homolog to C.elegans t37e11c.a

intraspecies

homolog to WNT1

Homologene

FAMILY

WNT family

CATEGORY

protooncogene , signaling

SUBCELLULAR LOCALIZATION	extracellular
text	associated with the extracellular matrix

basic FUNCTION	involved in short-range signaling during embryonic patterning
	playing a key role in carcinogenesis through activation of WNT-beta-catenin-TCF signaling pathway
	ligand for members of the frizzled family of seven transmembrane receptors
	WNT6, WNT10A and WNT10B inhibit adipogenesis and stimulate osteoblastogenesis through a CTNNB1-dependent mechanism

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal cancer with WNT10A tumoral     --over   in cervical cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS