Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol WNT5B contributors: mct - updated : 24-10-2018
HGNC name wingless-type MMTV integration site family, member 5B
HGNC id 16265
Location 12p13.33      Physical location : 1.726.221 - 1.756.377
Synonym symbol(s) MGC2648, WN5B
DNA
TYPE functioning gene
STRUCTURE 117.36 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2184 40.3 359 - 2017 27762090
WNT5B-V2
5 - 2251 40.3 359 - 2017 27762090
WNT5B-V1
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveintestinesmall intestine   
 liver    
Endocrinepancreas    
Nervousbrain   moderately
Reproductivefemale systemovary   
 male systemprostate  highly
Respiratorylung   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines gastric cancer cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain, lung, kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal signal peptide
  • four N linked glycosylation
  • HOMOLOGY
    intraspecies homolog to WNT5A
    Homologene
    FAMILY WNT family
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • may be involved in the pathogenesis of this disease through the regulation of adipocyte function
  • regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway
  • WNT3 and WNT5B are critical factors secreted from Transforming growth factor-induced mesenchymal cancer cells for instigating the epithelial cancer cell invasion along with the induction of secondary EMT phenotype
  • role of GPC4 and WNT5B in chondrocyte stacking underlying craniofacial cartilage morphogenesis
  • may play an important role in the tumorigenesis of Colorectal cancer
  • WNT5B induces tube formation by regulating the expression of SNAIl and SNAI2 proteins through activation of canonical and non-canonical WNT signalling pathways
  • WNT5B-associated exosomes promote cancer cell migration and proliferation in a paracrine manner
  • WNT5B signals locally as an early step in basal constriction and acts together with more widespread PTK2 activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CNBP up-regulates TBX2 and SMARCA5, and down-regulates WNT5B gene expression
  • significant correlation between WNT5B and WNT11 overall staining and presence of calcification, lipid score, fibrosis, and microvessels, in aortic valve calcification
  • IMP3 facilitates the transcription of SNAI2, which is necessary for TAZ nuclear localization and activation, by a mechanism that is also mediated by WNT5B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    could contribute to decreased adipogenesis observed in T2DM diabetic subjects
    Susceptibility to diabetes type 2
    Variant & Polymorphism SNP one SNP locus was strongly associated with type 2 diabetes
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS