Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol WNT2B contributors: mct - updated : 04-09-2018
HGNC name wingless-type MMTV integration site family, member 2B
HGNC id 12781
Corresponding disease
DIAR9 neonatal-onset chronic diarrhea, 9
Location 1p13.2      Physical location : 113.010.039 - 113.063.908
Synonym name
  • wingless-type MMTV integration site 13
  • XWNT2, Xenopus, homolog of
  • Synonym symbol(s) WNT13, XWNT2
    DNA
    TYPE functioning gene
    STRUCTURE 54.75 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC149620 1p13.2 similar to CHIA protein CHIA 1p21.3-p13.1 similar to CHIA protein LOC128344 1p13.2 hypothetical protein LOC128344 LOC388665 1 similar to DKFZP564K247 protein LOC391066 1 similar to pepsinogen B OVGP1 1p13 oviductal glycoprotein 1, 120kDa (mucin 9, oviductin) MEP50 1p13.2 MEP50 protein ATP5F1 1p12 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1 MGC24133 1p13.2 hypothetical protein MGC24133 AD026 1p13.1 AD026 protein ADORA3 1p13.3 adenosine A3 receptor RAP1A 1p13.3 RAP1A, member of RAS oncogene family LOC55924 1pter-q31.3 hypothetical protein LOC55924 DDX20 1p21.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 KCND3 1p13.2 potassium voltage-gated channel, Shal-related subfamily, member 3 AF357532 1q12 thioredoxin 1 pseudogene 5 DKFZp547A023 1p13.2 hypothetical protein DKFZp547A023 WNT2B 1p13 wingless-type MMTV integration site family, member 2B ST7L 1p12 suppression of tumorigenicity 7 like CAPZA1 1p13.1 capping protein (actin filament) muscle Z-line, alpha 1 MRPL53P1 1p13.2 capping protein (actin filament) muscle Z-line, alpha 1 MOV10 1p13.1 Mov10, Moloney leukemia virus 10, homolog (mouse) ARHC 1p21-p13 ras homolog gene family, member C LOC284467 1p13.1 TAFA3 MGC19531 1p13.1 hypothetical protein MGC19531 LOC128322 1p13.1 similar to Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15) LOC388666 1 hypothetical gene supported by AK093435 SLC16A1 1p13.2-p12 solute carrier family 16 (monocarboxylic acid transporters), member 1 LRIG2 1p13.1 leucine-rich repeats and immunoglobulin-like domains 2 RPS19P2 1p13.1 ribosomal protein S19 pseudogene 2 MAGI-3 1p12-p11.2 membrane-associated guanylate kinase-related (MAGI-3)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing initiation site 2925 41.6 372 fetal brain,fetal lung 2008 18155664
  • WNT2B1 lacking exon 3
  • 5 splicing initiation site 2515 43.8 391 fetal brain (caudate nucleus),lung, kidney,testis 2008 18155664
  • WNT2B2 lacking exons 1 and 2
  • 5 - 2854 - 299 - 2008 18155664
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Reproductivefemale systembreast   
     male systemtestis  highly
    Visualeye   highly
    cell lineage
    cell lines glioblastoma, gastric cancer, cervical cancer cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain, lung, kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal hydrophibic domain
  • a WNT core domain with 24 cysteine residues
  • two N-glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (wg) segment polarity gene
    Homologene
    FAMILY WNT family
    CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
    text
  • in the presence of ACSL5, WNT2B was unable to translocate into the nucleus and was enriched in mitochondria, which was paralleled by a significant decrease in Wnt activity
  • basic FUNCTION
  • modulating cell fate and cell behavior during vertebrate development
  • implicated in eye ciliary body induction
  • role for the lens in maintenance of WNT2B expression
  • WNT2B primarily plays a supportive role in gastrulation and organogenesis, functioning redundantly with canonical Wnts, such as WNT2, in numerous tissues
  • is likely required to maintain normal intestinal stem cells (ISCs) numbers and/or activity in the duodenum
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is one of canonical WNTs transducing signals through Frizzled (FZD) and LRP5/LRP6 receptors to beta-catenin-TCF/LEF signaling cascade
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DIAR9
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in several breast cancer cell lines
    constitutional       gain of function
    abnormal upregulation in the levels of WNT2B and WNT7B in neural tube defects (NTDs)
    tumoral     --over  
    of GLI1 and WNT2B might play a pivotal role during tumorigenesis of pancreatic cancer, and the high expression of WNT2B might be associated with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking Wnt2b were viable, fertile, and displayed a normal life span, however, the olfactory bulb in adult Wnt2b mutant mice was significantly reduced in length