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FLASH GENE
Symbol WNT16 contributors: mct/npt - updated : 28-03-2015
HGNC name wingless-type MMTV integration site family, member 16
HGNC id 16267
Location 7q31.31      Physical location : 120.965.420 - 120.981.157
Synonym name protein Wnt-16
DNA
TYPE virus associated
STRUCTURE 15.74 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence alternative promoter
MAPPING cloned Y linked N status provisional
Physical map
LSM8 7q31.1-q31.3 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) ANKRD7 7q31 ankyrin repeat domain 7 KCND2 7q31-q32 potassium voltage-gated channel, Shal-related subfamily, member 2 TM4SF12 7 transmembrane 4 superfamily member 12 ING3 7q31 inhibitor of growth family, member 3 FLJ21986 7q31.32 hypothetical protein FLJ21986 WNT16 7q31 wingless-type MMTV integration site family, member 16 FAM3C 7q22.1-q31.1 family with sequence similarity 3, member C HCP19 7q31.32 cytochrome c, somatic pseudogene LOC136143 7q31.32 similar to ribosomal protein L18; 60S ribosomal protein L18 PTPRZ1 7q31.3 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 AASS 7q31.3 aminoadipate-semialdehyde synthase LOC389549 7 similar to zinc finger protein 312; forebrain embryonic zinc finger CADPS2 7q31.1 Ca2+-dependent activator protein for secretion 2 RNF133 7q31.33 ring finger protein 133 RNF148 7q31.33 ring finger protein 148 TAS2R16 7q31.1-q31.3 taste receptor, type 2, member 16 SLC13A1 7q31-q32 solute carrier family 13 (sodium/sulfate symporters), member 1 FLJ35834 7q31.33 hypothetical protein FLJ35834 NDUFA5 7q31.33 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa ASB15 7q31.31 ankyrin repeat and SOCS box-containing 15 LOC389550 7 similar to cardiac leiomodin WASL 7q31.3 Wiskott-Aldrich syndrome-like HYAL4 7q31.3 hyaluronoglucosaminidase 4 SPAM1 7q31.3 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) LOC340344 7q31.33 similar to RIKEN cDNA 6332401O19 gene LOC136157 7q31.33 similar to RIKEN cDNA 1500011L16 LOC346643 7q31.33 similar to 40S ribosomal protein S2 GPR37 7q31 G protein-coupled receptor 37 (endothelin receptor type B-like) LOC154872 7q31.33 hypothetical LOC154872
RNA
TRANSCRIPTS type messenger
text two transcript variants diverging at the 5' termini and produced by separate promoters
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2894 - 355 - 2009 19951988
  • WNT16a (short form)
  • difference in the 5' terminus including 5' UTR and the coding region for the N-terminus (1st exon)
  • 4 initiation site 3132 40.7 365 expressed only in pancreas 2009 19951988
  • WNT16b
  • an hydrophobic signal peptide and many conserved cysteine residues
  • upregulated in basal cell carcinomas compared with normal skin
  • activated the Jun-N-terminal kinase cascade (may be involved in the activation of a non-canonical WNT signalling pathway)
  • activates keratinocyte proliferation possibly via a beta-catenin-independent non-canonical WNT transduction pathway
  • is a new marker of senescence that regulates TP53 activity and the PI3K/AKT pathway and is necessary for the onset of replicative senescence
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Nervousbrain    
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to C.elegans W08d2.1
    Homologene
    FAMILY
  • WNT family
  • CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text associated with the extracellular matrix
    basic FUNCTION
  • ligand for members of the frizzled family of seven transemembrane receptors
  • plays an important role in leukemogenesis, raising its therapeutic interest
  • is an important determinant of cortical bone thickness (CBT) and bone mineral density (BMD), bone strength, and risk of fracture
  • is involved in intramembranous ossification and suppresses osteoblast differentiation through the Wnt/CTNNB1 pathway
  • regulates the somitic expression of two Notch ligands, deltaC (dlc) and deltaD (dld), whose combined function is required for HSC fate
  • antagonistic role for WNT16 in the chondrogenic transformation of vascular smooth muscle cells (VSMCs)
  • attenuates TGFB-Induced chondrogenic transformation in vascular smooth muscle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis
    Susceptibility
  • to osteoporotic fractures
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS