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FLASH GENE
Symbol WNT11 contributors: mct - updated : 29-08-2016
HGNC name wingless-type MMTV integration site family, member 11
HGNC id 12776
Location 11q13.5      Physical location : 75.897.370 - 75.917.574
Synonym name protein Wnt-11
Synonym symbol(s) HWNT11, MGC141946, MGC141948
DNA
TYPE functioning gene
STRUCTURE 20.21 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
KCNE3 11q13-q14 potassium voltage-gated channel, Isk-related family, member 3 HCP27 11q13.3 cytochrome c, somatic pseudogene LOC387787 11 similar to RIKEN cDNA 2610209A20 POLD3 11q14 similar to RIKEN cDNA 2610209A20 BNF1 FLJ22596 11q13.3 hypothetical protein FLJ22596 LOC387788 11 similar to ribosomal protein S12 KIAA1991 11q13.3 hypothetical protein KIAA1991 KIAA0102 11q13.3 hypothetical protein KIAA1991 LOC387789 11 LOC387789 NEU3 11q13.5 sialidase 3 (membrane sialidase) LOC390224 11 similar to olfactory receptor MOR101-2 LOC341152 11q13.3 similar to olfactory receptor MOR101-1 LOC390225 11 similar to olfactory receptor MOR101-2 SLCO2B1 11q13 solute carrier organic anion transporter family, member 2B1 ARRB1 11q13 arrestin, beta 1 RPS3 11q13.3-q13.5 ribosomal protein S3 FLJ33790 11q13.3 hypothetical protein FLJ33790 PP1665 11q13.3 hypothetical protein PP1665 SERPINH1 11q13.5 serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) MAP6 6p12-p11 microtubule-associated protein 6 MGAT2 14q21 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase DGAT2 11q13.3 diacylglycerol O-acyltransferase homolog 2 (mouse) UVRAG 11q13 UV radiation resistance associated gene WNT11 11q13.5 wingless-type MMTV integration site family, member 11 PRKRIR 11q13.5 protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) LOC387790 11 LOC387790 C11orf30 11q13.5 chromosome 11 open reading frame 30 GARP 11q13.5-q14 glycoprotein A repetitions predominant LOC390226 11 similar to Olfactory guanylyl cyclase GC-D precursor (Guanylate cyclase, olfactory) E2IG4 11q13.3 hypothetical protein, estradiol-induced PHCA 11q13.4 phytoceramidase, alkaline IMAGE:4907098 11q13.4 beta-1,3-N-acetylglucosaminyltransferase protein CAPN5 11q14 calpain 5 OMP 11q13 olfactory marker protein MYO7A 11q13.5 myosin VIIA (Usher syndrome 1B (autosomal recessive, severe)) LOC220032 11q13.4 GDPD domain containing protein LOC387791 11 similar to Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20) PAK1 11q13.5-q14.1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) LOC387792 11 LOC387792 AQP11 11q13.4 aquaporin 11 CLNS1A 11q13.5-q14.1 chloride channel, nucleotide-sensitive, 1A HBXAP 11q13.4-q14.1 hepatitis B virus x associated protein PTD015 11q13.4 PTD015 protein MGC16733 11q13.4 hypothetical gene MGC16733 similar to CG12113
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1927 36.6 354 - 1998 9757009
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineparathyroid   highly
Reproductivefemale systemovary   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion secreted
at STAGE
physiological period fetal, pregnancy
Text in the perichondrium of the developing skeleton and in the tips of ureteric buds, liver, kidney, heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cysteine rich, with a zinc finger-like motif
  • five glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (Wg) segment polarity gene
    Homologene
    FAMILY
  • WNT family
  • frizzled gene subfamily
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • ligand for the members of the frizzled members of receptors,modulating cell fate and cell behavior during vertebrate development
  • not required for cardiac differentiation, but functioning in regulation of cardiac morphogenesis
  • may be playing an important role in carcinogenesis through activation of the WNT signaling pathway
  • may be a key regulator of cardiac muscle cell proliferation and differentiation during heart development
  • has an essential role in the oriented elongation of the myocytes
  • required to control myocyte orientation and the action of the neural tube on the polarized elongation of myocytes is mediated, at least in part, by WNT11
  • involved in coordination of key signaling pathways
  • promotes osteoblast maturation and mineralization, through RSPO2
  • regulates the integration of intracellular and extracellular Ca2+, while also tuning dynamic relationships between subcellular Ca2+ domains, and refinement of electrical coupling by Wnt signals may be an important factor not only in cardiogenesis, but also in the establishment and maintenance of other epithelia in development
  • promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals
  • WNT5A and WNT11 are essential regulators of the response of second heart field progenitors to WNT/CTNNB1 signaling and they act by restraining WNT/CTNNB1 signaling during cardiac development
  • plays a crucial role in regulating MSC chondrogenic differentiation
  • WNT5A and WNT11 regulate epithelial-mesenchymal transition (EMT) by inducing p38 (MAPK14) phosphorylation
  • plays an important role in human mesenchymal stem cells (hMSCs) for enhancing the osteogenesis in an infectious environment
  • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS development
    text skeleton, kidney, lung, heart
    PATHWAY
    metabolism
    signaling signal transduction
    WNT signaling pahway, JNK/AP-1 and NF-kappaB signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a direct target of ERG (potent ERG induction promoted morphological transformation through WNT11 signals
  • WNT-11/FZD7 controls cell adhesion by forming separate adhesion-modulating complexes (AMCs) with the paraxial protocadherin PCDH8 and C-cadherin via distinct FZD7 interaction domains
  • WLS has different roles in the polarized secretion of WNT11 and WNT3A and glycosylation processing of Wnts decides their secretory routes
  • stimulates proliferation, migration and invasion of cancer-derived cells, and increases activity of matrix metalloproteinase (MMP2 and MMP9)
  • significant correlation between WNT5B and WNT11 overall staining and presence of calcification, lipid score, fibrosis, and microvessels, in aortic valve calcification
  • cell & other
    REGULATION
    induced by hypoxia
    Other transcription of WNT11 is regulated primarily by HIF1A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal and gastric cancer
    Susceptibility to high bone mass syndrome
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    as a possible target for cancer therapies, especially for tumors treated with antiangiogenic therapy
    ANIMAL & CELL MODELS
    WNT11 is required for heart formation in Xenopus embryos. This function is conserved in higher vertebrates (mice). The effect is mediated by non-cammical Wnt signaling which involves protein kinase C and Jun amino-terminal kinase