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FLASH GENE
Symbol WNT10A contributors: mct/npt - updated : 22-02-2016
HGNC name wingless-type MMTV integration site family, member 10A
HGNC id 13829
Corresponding disease
OODD odonto-onycho-dermal dysplasia
SSPS Schopf-Schulz-Passarge syndrome
STHAG4 selective tooth agenesis 4
Location 2q35      Physical location : 219.745.254 - 219.758.651
Synonym symbol(s) WN1A, FLJ14301
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster, head to head
text clustered with WNT6 in a head to tail manner with an interval of less than 7kb
STRUCTURE 19.61 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
USP37 2q35 ubiquitin specific protease 37 RQCD1 2q36.1 RCD1 required for cell differentiation1 homolog (S. pombe) PLCD4 2q35 phospholipase C, delta 4 ZNF142 2q34-q35 zinc finger protein 142 (clone pHZ-49) BCS1L 2q33 BCS1-like (yeast) RNF25 2q36.1 ring finger protein 25 STK36 2q35 serine/threonine kinase 36 (fused homolog, Drosophila) KIAA0173 2p24.3-p24.1 serine/threonine kinase 36 (fused homolog, Drosophila) CYP27A1 2q35-q36 cytochrome P450, family 27, subfamily A, polypeptide 1 PRKAG3 2q35 protein kinase, AMP-activated, gamma 3 non-catalytic subunit LOC391484 2 similar to 60S ribosomal protein L23a WNT6 2q35 wingless-type MMTV integration site family, member 6 WNT10A 2q35 wingless-type MMTV integration site family, member 10A LOC391485 2 similar to cytokeratin 8 CDK5R2 2q35 cyclin-dependent kinase 5, regulatory subunit 2 (p39) HSRNAFEV 2q33 cyclin-dependent kinase 5, regulatory subunit 2 (p39) CRYBA2 2q34-q36 crystallin, beta A2 DKFZp434O0527 2q36.1 hypothetical protein DKFZp434O0527 MGC35338 2q36.1 hypothetical protein MGC35338 IHH 2q35-q36 Indian hedgehog homolog (Drosophila) FLJ12610 2q36.1 hypothetical protein FLJ12610 SLC23A3 2q36.1 solute carrier family 23 (nucleobase transporters), member 3 CGI-57 2q36.1 hypothetical protein CGI-57 MGC3035 LOC130617 2q36.1 hypothetical protein BC018415 ABCB6 2q33-q36 ATP-binding cassette, sub-family B (MDR/TAP), member 6 FLJ22169 2q36.1 hypothetical protein FLJ22169 FLJ10415 2q36.1 hypothetical protein FLJ10415
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3000 - - - 2007 17286598
4 - 2375 46.4 417 - 2007 17286598
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
Reproductivefemale systemovary  lowly
 male systemprostate   
Urinarykidney    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines promyelocystic leukemia Burkitt's lymphoma cell lines and strongly coexpressed with WNT6 in colorestal cancer cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta, moderatly in kidney, lowly in lung, expressed in the epithelial signaling centers regulating tooth development (Yamashiro 2007)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-linked glycosylation sites
  • an N terminal signal peptide WNT core domain and an RGD motif
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Wnt6
    homolog to C.elegans Y37e11c.A
    homolog to murine Wnt10a
    intraspecies homolog to WNT10B
    Homologene
    FAMILY
  • WNT family
  • CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
    text associated with the extracellular matrix
    basic FUNCTION
  • invoved in oncogenesis and in several developmental process including regulation of cell fate and patterning during embyogenesis
  • playing a key role in carcinogenesis through activation of WNT-beta-catenin-TCF signaling pathway
  • ligand for members of the frizzled family of seven transmembrane receptors
  • plays a crucial role in the development and/or regulation of the ectodermal derivatives
  • key molecule for dentinogenesis and that it is associated with the cell-matrix interactions regulating odontoblast differentiation (Yamashiro 2007)
  • WNT6, WNT10A and WNT10B inhibit adipogenesis and stimulate osteoblastogenesis through a CTNNB1-dependent mechanism
  • may induce kidney fibrosis and associate with kidney dysfunction in acute interstitial nephritis (AIN)
  • acts as an oncofetal factor that is highly expressed and may promote proper development of the esophagus
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • upstream regulatory molecule for DSPP expression (cell-matrix interaction is essential for induction of DSPP expression) (Yamashiro 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OODD , SSPS , STHAG4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    tumoral     --over  
    in cervical cancer
    tumoral     --over  
    in esophageal squamous cell carcinoma
    constitutional     --low  
    affects odontogenesis and proliferation in mesenchymal cells
    Susceptibility to keratoconus
    Variant & Polymorphism SNP
  • rs121908120 increases the risk of keratoconus
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS