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FLASH GENE
Symbol WNT1 contributors: shn - updated : 22-03-2017
HGNC name wingless-type MMTV integration site family, member 1
HGNC id 12774
Corresponding disease
OIXV osteogenesis imperfecta, type XV
Location 12q13.12      Physical location : 49.372.235 - 49.376.395
Synonym name
  • proto-oncogene Int-1 homolog
  • proto-oncogene Wnt-1
  • wingless-type MMTV integration site family, member 1 (oncogene INT1)
    • Synonym symbol(s) INT1, BMND16, OI15
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster, head to head, opposite orientation
    text clustered with WNT10B, in a head to head manner with an interval of less than 7kb
    STRUCTURE 4.16 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D12S2196 - D12S339 - WNT1 - D12S1590 - D12S1627 - qter
    Authors Merscher(97)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2284 - 370 - 2002 11782388
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Skeleton      Homo sapiensAdult
           Homo sapiensFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skeletonosteoblast Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text cerebellum
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • an hydrophobic leader domain, cysteine rich
  • a set of 22 conserved cysteine residues that form the intrachain disulfide bridges that maintain the tertiary protein structure
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to wnt1, Danio rerio
    ortholog to Wnt1, Rattus norvegicus
    ortholog to Wnt1, Mus musculus
    ortholog to wg, Drosophila melanogaster
    intraspecies homolog to WNT6
    Homologene
    FAMILY
  • WNT gene family
    • CATEGORY secretory , protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text associated with the extracellular matrix
    basic FUNCTION
  • normal function may be in spermatogenesis and in the development of the central nervous system
  • involved in early development of a large domain of the central nervous system encompassing much of the midbrain and rostral metencephalon
  • instructs early eural crest stem cells to adopt a sensory neuronal fate in a beta-catenin-dependent manner
  • role in patterning of the midbrain region and specifying dopaminergic progenitors or regulating survival
  • implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis
  • role in the induction of the mesencephalon and cerebellum
  • early requirement of WNT1 for all midbrain dopamine (MbDA) neurons
  • plays a crucial role in bone formation and bone-remodeling processes
  • in the bone compartment, WNT1 influences the osteoblast lineage itself or some adjacent cell type
  • involvement of WNT1 and FZD1 in the pathogenesis and development of ALS
  • HIF1A-dependent induction of WNT1 in hypoxic macrophages undermines autophagy in epithelial cells
  • importance of palmitoylation for WNT1 activity and PORCN is an O-acyl transferase for WNT1
  • WNT1 stimulates osteogenic differentiation and mineralization of human periodontal ligament fibroblasts (hPLFs), mainly by activating the canonical WNT/CTNNB1 pathway, in which RUNX2 is a key downstream regulator
  • during macrophage differentiation from monocytes, WNT1 promotes CD36 expression via activation of PPARG and TCF4
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    text neuronal development
    PATHWAY
    metabolism
    signaling signal transduction
    cell-to-cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Frizzled related proteins, FRP
  • PORCN, RSPO1, RSPO2 and RSPO3
  • WNT1 enhances the proliferative and angiogenic functions of human endothelial progenitor cells (hEPCs) in a hepatocyte growth factor (HGF)-dependent manner
  • WNT1 induces GLI1 expression in a SULF2- and CTNNB1-dependent manner
  • WNT1 residues 214-234 are sufficient for PORCN-dependent palmitoylation of Ser224
  • WNT1 regulates the expression of CD36 through TCF4 and PPARG
  • WNT1-induced MAFK expression promotes osteosarcoma cell proliferation
  • PORCN and WLS compete for binding to WNT1
  • interplay of WNT1-LEF1 and TGFB1-SMAD3 signaling activates canonical WNT1 target promoters in a manner that depends on CTNNB1 during myoblast proliferation but is independent of CTNNB1 during Skeletal muscle stem cells (MuSCs) quiescence
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OIXV
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of SOX9, WNT1, FZD1, and Ki-67 proteins occurred more frequently in human osteosarcoma tissues with an advanced clinical stage
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    targeting Wnt1-associated signaling proteins may provide an effective therapeutic approach for the treatment of advanced breast cancer
    ANIMAL & CELL MODELS
  • mice surexpressing Wnt1 display mammary gland hyperplasia and adenocarcinomas
  • mice homozygous for Wnt1 null mutation exhibit a range of phenotypes from death before birth to survival with severe ataxia including severe abnormalities in the development of the mesencephalon and metencephalon