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FLASH GENE
Symbol WLS contributors: mct/npt/pgu - updated : 04-10-2013
HGNC name wntless homolog (Drosophila)
HGNC id 30238
Location 1p31.3      Physical location : 68.564.142 - 68.698.284
Synonym name
  • chromosome 1 open reading frame 139
  • wntless homolog
  • protein evenness interrupted homolog
  • putative NFkB-activating protein 373
  • G protein-coupled receptor 177
  • Synonym symbol(s) FLJ23091, MRP, C1orf139, EVI, MGC131760, MGC14878, GPR177
    DNA
    TYPE functioning gene
    STRUCTURE 134.10 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2780 62.12 541 - 2006 16710414
    12 - 2095 62.6 545 - 2006 16710414
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to Drosophila Wntless/Evi/Sprinter
    Homologene
    FAMILY
  • wntless family
  • CATEGORY chaperone/stress , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • localized to the basolateral membrane
  • basic FUNCTION
  • plays a critical role in mediating Wnt protein secretion from Wnt producing cells
  • role in regulating cellular response to opioid drugs
  • transports WNT from the Golgi network to the cell surface for release
  • WLS-recycling is mediated through a retromer pathway that is independent of the retromer sorting nexins SNX1-SNX2 and SNX5-SNX6
  • trafficking of WLSs is required for efficient secretion of WNT signaling proteins
  • essential regulator of glioma tumourigenesis
  • chaperone protein that specifically escorts WNT ligands for secretion
  • required for WNT ligand secretion by WNT-producing cells, specifically in the hair follicle epithelium during telogen phase
  • chaperon protein important for the sorting and secretion of Wnt proteins
  • regulates pulmonary vasculature development
  • Wnt-specific transmembrane transporter
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with OPRM1 (morphine-mediated OPRM1/WLS interaction may result in decreased Wnt secretion in the CNS, resulting in atrophy of dendritic arbors and decreased neurogenesis)
  • interaction with WNT (reciprocal regulation of Wnt and WLS is essential for the patterning of the anterior-posterior axis during mammalian development)
  • SNX3 has an evolutionarily conserved function in WLS recycling and WNT secretion
  • SNX3 is part of an alternative retromer pathway that functionally separates the retrograde transport of WLS from other retromer cargo
  • SNX3 acts as a cargo-specific component of retromer, which is required for endocytic recycling of WLS and Wg/WNT secretion
  • has different roles in the polarized secretion of WNT11 and WNT3A and glycosylation processing of Wnts decides their secretory routes
  • WLS binds to RAB8A
  • PORCN and WLS compete for binding to WNT1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    affects Wnt production in the signal-producing cells, leading to alterations of Wnt signaling in the signal-receiving cells
    constitutional       loss of function
    loss of WLS in the follicular epithelium resulted in a profound hair cycle arrest
    constitutional     --low  
    WLS-deficient osteoblasts had a defect in differentiation and mineralization, with significant reductions in the expression of key osteoblast differentiation regulators
    tumoral     --over  
    in astrocytic gliomas
    Susceptibility to osteoporosis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS