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FLASH GENE
Symbol WIZ contributors: mct - updated : 08-11-2016
HGNC name widely interspaced zinc finger motifs
HGNC id 30917
Location 19p13.12      Physical location : 15.532.318 - 15.560.762
Synonym name
  • zinc finger protein 803
  • Synonym symbol(s) ZNF803
    DNA
    TYPE functioning gene
    STRUCTURE 28.45 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    OR7A17 19p13.13 olfactory receptor, family 7, subfamily A, member 17 OR7A18P 19p13.13 olfactory receptor, family 7, subfamily A, member 18 pseudogene LOC390895 19 similar to olfactory receptor, family 7, subfamily A, member 17 OR7A14P 19p13.1 olfactory receptor, family 7, subfamily A, member 14 pseudogene OR7A11P 19p13.1 olfactory receptor, family 7, subfamily A, member 11 pseudogene OR7A15P 19p13.1 olfactory receptor, family 7, subfamily A, member 15 pseudogene OR7C2 19p13.1 olfactory receptor, family 7, subfamily C, member 2 SLC1A6 19p13.11 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 FLJ40365 19p13.13 hypothetical protein FLJ40365 CASP14 19p13.1 caspase 14, apoptosis-related cysteine protease LOC126370 19p13.13 similar to Olfactory receptor 1I1 (Olfactory receptor 19-20) (OR19-20) 7h3 19p13.13 hypothetical protein FLJ13511 ILVBL 19p13.1 ilvB (bacterial acetolactate synthase)-like NOTCH3 19p13.2-p13.1 Notch homolog 3 (Drosophila) ABHD9 19p13.13 abhydrolase domain containing 9 BRD4 19p13.1 bromodomain containing 4 AKAP8 19p13.1-q12 a kinase (PRKA) anchor protein 8 NAKAP95 19p13.12-p13.11 a kinase (PRKA) anchor protein 8 WIZ 19p13.1 widely-interspaced zinc finger motifs FLJ21438 19p13.12 hypothetical protein FLJ21438 PGRP-L 19p13.12 peptidoglycan recognition protein L precursor FLJ39501 19p13.12 hypothetical protein FLJ39501 LOC390896 19 similar to Cytochrome P450 4F6 (CYPIVF6) LOC388513 19 similar to 60S ribosomal protein L23a CYP4F8 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 8 CYP4F3 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 3 CYP4F12 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 12 OR10H2 19p13.1 olfactory receptor, family 10, subfamily H, member 2 OR10H3 19p13.1 olfactory receptor, family 10, subfamily H, member 3 LOC388514 19 similar to Cytochrome P450 4F12 (CYPIVF12)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 4185 - 794 - 2015 26338712
    - - 4218 - 835 - 2015 26338712
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • role for WIZ in neural function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EHMT2/EHMT1-associating zinc finger molecule named WIZ that can interact with EHMT2 and EHMT1 independently but is more stable in the EHMT2/EHMT1 heteromeric complexes
  • WIZ interact with the transcription activation domain of EHMT1
  • WIZ regulates global H3K9me2 levels by facilitating the interaction of EHMT2 with chromatin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   amplification    
    micoduplication in bladder exstrophy-epispadias complex
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS