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FLASH GENE
Symbol WIPF2 contributors: mlc - updated : 20-06-2005
HGNC name WAS/WASL interacting protein family, member 2
HGNC id 30923
Location 17q21.2      Physical location : 38.375.573 - 38.438.439
Synonym name
  • WIP- and CR16-homologous protein
  • WIRE protein
  • WASP-interacting protein-related protein
  • Synonym symbol(s) WIRE, WICH
    DNA
    TYPE functioning gene
    STRUCTURE 63.00 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  moderately
     pancreas exocrine   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain   moderately
    Reproductivefemale systemuteruscervix predominantly
     female systembreastmammary gland moderately
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a WH2 domain
    HOMOLOGY
    interspecies ortholog to murine Wipf2 (89 pc)
    Homologene
    FAMILY Verprolin family
    CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text localized to stress fibers and bundles of actin filaments
    basic FUNCTION
  • playing an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors
  • playing an important role in actin-microspike formation through cooperation with WASL
  • may cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system
  • being a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery
  • actin bundling protein
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WASL/WIPF2 serves as an integrator that couples actin nucleation with the subsequent steps of filament stabilization and organization necessary for zonula adherens integrity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WASL
  • WAS
  • NCK2
  • binds to actin filaments but also cross-links them
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS