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FLASH GENE
Symbol WIBG contributors: mct/npt - updated : 23-10-2009
HGNC name within bgcn homolog (Drosophila)
HGNC id 30258
Location 12q13.2      Physical location : 56.295.196 - 56.321.697
Synonym name protein wibg homolog
Synonym symbol(s) PYM, MGC13064
DNA
TYPE functioning gene
STRUCTURE 26.50 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1105 - 203 - Diem (2007)
3 - 1244 29 204 - Diem (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
 vessel   moderately
Lymphoid/Immunespleen   highly
Nervousbrain   moderately
Reproductivefemale systemuteruscervix predominantly
 female systemovary  moderately
Respiratoryrespiratory tractlarynx  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Wibg
Homologene
FAMILY
  • wibg family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • functions as a bridge between exon-junction complex -bearing spliced mRNAs and the translation machinery to enhance translation of the mRNAs (Diem 2007)
  • ribosome-associated protein acting as an exon-junction complex disassembly factor (Gehring 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds the RBM8A-MAGOH complex in the cytoplasm, and also binds, via a separate domain, to the small (40S) ribosomal subunit and the 48S preinitiation complex (Diem 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS