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FLASH GENE

Symbol

WFIKKN2

contributors: mct - updated : 30-04-2014

HGNC name	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
HGNC id	30916

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.33      Physical location : 48.912.604 - 48.919.707
Synonym name	multivalent protease inhibitor protein
	WAP, FS, Ig, two KU and NTR module related protein
	growth and differentiation factor-associated serum protein 1
Synonym symbol(s)	WFIKKNRP, GASP-1, WFDC20B, hGASP-1

DNA

TYPE	functioning gene
STRUCTURE	7.10 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_175575 2 - 3765 NP_783165 - 576 - 2003 1270907

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       highly Mus musculus Lymphoid/Immune thymus       highly Mus musculus Nervous brain       moderately Reproductive female system ovary     moderately Mus musculus   male system testis     moderately Mus musculus Visual eye       highly Mus musculus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum       Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

Text	primarily in fetal brain, skeletal muscle, thymus, and kidney

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a WAP domain
	many conserved domains associated with protease-inhibitory proteins, including a whey acidic protein domain
	a follistatin/Kazal domain
	an Ig domain
	two tandem Kunitz domains
	a netrin domain

HOMOLOGY

interspecies

ortholog to murine Wfikkn2

intraspecies

paralog to WFIKKN1

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	may control the action of multiple types of proteases
	in brain may be regulating the action of GDF11
	both WFIKKN2 and WFIKKN1 act by blocking the initial binding of the ligand to its receptor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds mature MSTN/myostatin and myostatin propeptide and inhibits the biological activity of myostatin
	with WFIKKN1, also binds to GDF11
	WFIKKN1 and WFIKKN2 proteins are antagonists of MSTN and GDF11, but in the case of TGFB1, BMP2 and BMP4 they function as growth factor binding proteins
	both WFIKKN1 and WFIKKN2 bind MSTN and GDF11 (growth and differentiation factor 11) with high affinity and are potent antagonists of these growth factors
	interactions with MSTN and GDF11 are mediated primarily by the follistatin and NTR domains
	WFIKKN1 may have greater potential as an antimyostatic agent than WFIKKN2
	WFIKKN1 and WFIKKN2 are important modulators of GDF11 and MSTN activity

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS