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FLASH GENE
Symbol WFIKKN1 contributors: mct/npt - updated : 29-04-2014
HGNC name WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
HGNC id 30912
Location 16p13.3      Physical location : 681.011 - 684.116
Synonym name
  • WAP, FS, Ig, KU and NTR - containing protein
  • potential multiprotease inhibitor
  • chromosome 16 open reading frame 12
  • growth and differentiation factor-associated serum protein 2
  • Synonym symbol(s) RJD2, WFIKKN, C16orf12, MGC126651, MGC126655, GASP-2, WFDC20A
    DNA
    TYPE functioning gene
    STRUCTURE 3.10 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1948 56.7 548 - 2003 12709070
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Mus musculus
    Urinarykidney     Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, in the lung with weaker expression in skeletal muscle and liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • a whey acidic protein (WAP) domain
  • a domain homologous with follistatin modules of the kazal-domain family (FS)
  • an Ig-related domain
  • two tandem domains related to Kunitz-type protease inhibitor modules (KU)
  • a domain belonging to the NTR-module family
  • HOMOLOGY
    Homologene
    FAMILY
  • WFIKKN family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • may be involved in inhibition of various type of protease (serine proteases and metalloproteinases)
  • may be trypsin specific
  • in liver may play a crucial role in regulating the action of GDF11
  • WFIKKN1 may have greater potential as an antimyostatic agent than WFIKKN2
  • both WFIKKN2 and WFIKKN1 act by blocking the initial binding of the ligand to its receptor
  • plays an important role in modulating the activity of GDF11 during embryogenesis
  • plays an important role in axial skeletal patterning, most likely by regulating the activity of GDF11 in the posterior region of the developing embryo, where segment identity is being specified
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • trypsin
  • also binds to both myostatin and myostatin propeptide
  • with WFIKKN2, binds to GDF11
  • WFIKKN1 and WFIKKN2 proteins are antagonists of MSTN and GDF11, but in the case of TGFB1, BMP2 and BMP4 they function as growth factor binding proteins
  • both WFIKKN1 and WFIKKN2 bind MSTN and GDF11 (growth and differentiation factor 11) with high affinity and are potent antagonists of these growth factors
  • interactions with MSTN and GDF11 are mediated primarily by the follistatin and NTR domains
  • WFIKKN1 and WFIKKN2 are important modulators of GDF11 and MSTN activity
  • binds both mature myostatin and myostatin propeptide
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Gasp2-/- mice have posteriorly directed transformations of the axial skeleton, which contrast with the anteriorly directed transformations seen in Gdf11-/- mice