Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol WFDC5 contributors: mct - updated : 25-05-2011
HGNC name WAP four-disulfide core domain 5
HGNC id 20477
Location 20q13.11      Physical location : 43.738.092 - 43.743.803
Synonym name
  • protease inhibitor WAP1
  • whey acidic protein
    • Synonym symbol(s) WAP1, dJ211D12.5, PRG5, WAP
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 5.71 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • promoter region was highly conserved, as in other species with milk WFDC5
  • promoter was responsible for the lactogenic hormones
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1008 - 123 - 2006 16462094
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly Homo sapiens
     salivary gland   highly Homo sapiens
    Reproductivemale systemtestis   
     male systemmale genital tractepididymis  
    Respiratoryrespiratory tracttrachea  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text pregnant uterus
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal signal peptide
  • two WAP-type domains (Whey acidic proteins), WAP domains playing pivotal roles in the antimicrobial and/or antiprotease activities and their application in therapeutics are expected to have practical value
    • HOMOLOGY
    interspecies homolog to murine Wfdc5
    Homologene
    FAMILY WAP-type four-disulfide core (WFDC) domain family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be playing a role in host defence against invading micro-organisms or in the regulation of endogenous proteolytic enzymes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by NFIB (involved in the cooperative regulation of whey acidic protein (WFDC5) gene transcription along with the glucocorticoid receptor and STAT5
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS