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FLASH GENE
Symbol WDR74 contributors: mct - updated : 09-11-2021
HGNC name WD repeat domain 74
HGNC id 25529
Location 11q12.3      Physical location : 62.600.383 - 62.607.628
Synonym name
  • NOP seven-associated protein 1
  • Synonym symbol(s) Nsa1, FLJ10439, FLJ21730
    DNA
    TYPE functioning gene
    STRUCTURE 8.90 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1390 - 385 - 2020 31838084
    9 - 1254 - 366 - 2020 31838084
    12 - 1737 - 385 - 2020 31838084
    10 - 1629 - 385 - 2020 31838084
    11 - 1219 - 385 - 2020 31838084
    11 - 1261 - 399 - 2020 31838084
    13 - 1806 - 250 - 2020 31838084
    12 - 1341 - 250 - 2020 31838084
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to yeast Nsa1, a 60S ribosome assembly factor in yeast
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • WDR74 is a novel regulatory protein of the MTREX-exsosome complex whose interaction is regulated by NVL and is involved in ribosome biogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WDR74 is a factor that specifically dissociates from the complex depending on the ATPase activity of NVL
  • WDR74 associates with the D1 AAA domain of NVL, which represents a novel mode of binding of a substrate with a type II AAA-ATPase
  • WDR74 associates with MTREX, the nuclear exosome-assisting RNA helicase, whose dissociation is prohibited by an ATPase-deficient mutant of the AAA-type chaperone NVL
  • dissociation of WDR74 from MTREX in a late stage of rRNA synthesis is thought to be required for appropriate maturation of the pre-60S particles
  • critical role of WDR74 in regulating TGFB1 signaling
  • WDR74 is a MTREX-interacting partner, whose dissociation is stimulated by the ATP hydrolysis of NVL
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    upon lung cancer progression from healthy normal tissues to the primary cancer and further to the metastatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • can serve as a candidate target for the prevention and treatment of lung cancer
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in Wdr74-deficient mouse embryos blocking Trp53 function rescues blastocyst formation and lineage differentiation