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FLASH GENE
Symbol WDR73 contributors: mct - updated : 07-01-2015
HGNC name WD repeat domain 73
HGNC id 25928
Corresponding disease
GMS Galloway-Mowat syndrome
Location 15q25.2      Physical location : 85.186.011 - 85.197.521
Synonym symbol(s) HSPC264
DNA
TYPE functioning gene
STRUCTURE 11.91 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1855 - 378 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbraincerebellum   Homo sapiens
Urinarykidney     Homo sapiensFetal
cells
SystemCellPubmedSpeciesStageRna symbol
Urinarypodocyte Homo sapiensFetal
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six WD40 motifs
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • diffuse in the cytosol during interphase and enriched at the spindle poles and microtubule asters during mitosis
  • basic FUNCTION
  • WD40-repeat-containing protein, cell-cycle dependent
  • crucial role for WDR73 in the regulation of microtubule dynamics and organization during interphase
  • potential role for WDR73 in cell survival and microtubule regulation
  • potentially playing a crucial role in the development and maturation of the nervous system and in the maintenance of the proper function and integrity of glomerular filtration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GMS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS