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FLASH GENE
Symbol WDR72 contributors: mct/npt - updated : 03-12-2009
HGNC name WD repeat domain 72
HGNC id 26790
Corresponding disease
AIH5 amelogenesis imperfecta 5, hypoplastic/hypomaturation
Location 15q21.3      Physical location : 53.805.937 - 54.051.859
Synonym symbol(s) FLJ38736, MGC126663, MGC126665
DNA
TYPE functioning gene
STRUCTURE 245.92 kb     20 Exon(s)
text structure 19 coding exons (El Sayed 2009)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 7326 - 1102 - Gerhard (2004)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtoothenamel  
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveameloblast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven WD40 domains within the first 600 Aas from the N terminus
  • beta propeller domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    text intracellular localization in maturation-stage ameloblasts (El-Sayed 2009)
    basic FUNCTION
  • beta propeller may be a scaffold for protein-protein interactions (El-Sayed 2009)
  • potentially critical to ameloblast vesicle turnover during enamel maturation (El-Sayed 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AIH5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS