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FLASH GENE
Symbol WDR7 contributors: mct - updated : 29-04-2011
HGNC name WD repeat domain 7
HGNC id 13490
Location 18q21.31      Physical location : 54.318.615 - 54.697.036
Synonym name
  • TGFB resistance associated gene
  • TGF-beta resistance-associated protein TRAG
  • rabconnectin-3 beta
  • Synonym symbol(s) KIAA0541, TRAG, RAB3ACB, RBCN-3b
    DNA
    TYPE functioning gene
    STRUCTURE 378.42 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 splicing 7060 163.8 1490 - 2003 12786944
    27 - 7183 - 1457 - 2003 12786944
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text all embryon tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 7 WD domains
  • HOMOLOGY
    Homologene
    FAMILY
  • WD repeat gene family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text co-localized with rabconnectin-3 (DMXL2) on synaptic vesicles (
    basic FUNCTION
  • involved in cell cycle progression ,signal transduction, apoptosis and gene regulation
  • coregulator of Ca2+ dependent exocytosis of neurotransmitter
  • required for the Notch pathway
  • targeting of WDR7 significantly affected Notch signaling in several different mammalian cell types and, in particular, had a significant effect on osteoclast differentiation
  • necessary for proper Notch signaling in mammalian keratinocytes
  • likely influences Notch signaling through its involvement in the acidification of intracellular compartments via the V-ATPase complex
  • CELLULAR PROCESS cell cycle, progression
    cell life, cell death/apoptosis
    protein
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • associating with rabconnectin-3 alpha, and formed a stable complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding directly Rab3 GDP/GTP exchange protein
  • directly bound RAB3GAP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS