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FLASH GENE
Symbol WDR62 contributors: np/mct - updated : 29-09-2015
HGNC name WD repeat domain 62
HGNC id 24502
Corresponding disease
MCPCM microcephaly with cortical malformations
MCPH2 microcephaly primary (or true) 2
Location 19q13.12      Physical location : 36.545.782 - 36.596.012
Synonym name
  • chromosome 19 open reading frame 14
  • WD repeat-containing protein 62
  • Synonym symbol(s) C19orf14, DKFZP434J046, FLJ33298, DKFZp686G1024
    DNA
    TYPE functioning gene
    STRUCTURE 50.23 kb     32 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    32 - 4746 175 1523 - 2010 19910486
    32 - 4731 - 1518 - 2010 19910486
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   predominantly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text expressed in neuronal precursors as well as in postmitotic neurons in the developing brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • WD40-repeat region is required for microtubule association
  • MAPKBP1 and WDR62 share the same structural organization with their N-terminal half characterized by the presence of WD40 repeats
  • MAPKBP1 and WDR62 also share a highly conserved C-terminal coiled-coil containing region that is required for WDR62 homodimerization and some evidence indicates that it might also be involved in MAPKBP1-WDR62 heterodimerization
  • C-terminal region harbors a novel dimerization domain composed of a putative loop-helix domain that is necessary and sufficient for WDR62 dimerization and is critical for its scaffolding function , and the disordered C-terminal region regulates cell-cycle-dependent compartmentalization
  • conjugated
    HOMOLOGY
    intraspecies paralog to MAPKBP1
    Homologene
    FAMILY
    CATEGORY signaling neurotransmitter
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    text
  • not apparently associate with centrosomes and is predominantly nuclear in localization
  • in interphase cells, WDR62 had weak, diffuse cytoplasmic expression and was not nuclear
  • MAPKBP1 is recruited to mitotic spindle poles (MSPs) during the early phases of mitosis where it colocalizes with its paralog WDR62, which plays a key role at MSP
  • basic FUNCTION
  • scaffold JNK-binding protein, potentiating JNK kinase activity
  • recruited to stress granules and mediates a nonclassical JNK activation
  • WD40 repeat-containing protein which localizes to the spindle poles of dividing cells
  • spindle pole protein that is expressed in neuronal precursor cells undergoing mitosis in the mammalian embryonic neuroepithelium
  • acts at a critical hub of human cerebral development
  • requirement for MAPK/WDR62 signaling in mitotic spindle regulation that may be involved in coordinating neurogenesis
  • has a role in early cortical development
  • is a novel scaffold protein of the c-Jun N-terminal kinase (JNK) pathway
  • acts upstream of JNK signaling in the control of neurogenesis
  • is required for proper neurogenesis via MAPK8, providing an insight into the molecular mechanisms underlying MCPH pathogenesis
  • spindle pole protein required for normal cell division and neuroprogenitor differentiation during brain development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
  • part of a mitogen-activated protein kinase (MAPK) signaling cascade
  • MAPKBP1 homodimerizes and heterodimerizes with WDR62
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding partner of the centrosomal protein CEP170, which is of interest given the involvement of other centrosomal proteins in microcephaly
  • WDR62 specifically recruits MAPK8, but not MAPK9, to the spindle pole
  • AURKA-mediated phosphorylation was required for the spindle localization of WDR62 during mitosis
  • CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome, and they interact to promote centriole duplication
  • WDR62 interacting with MOONRAKER (KIAA0753)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH2 , MCPCM
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    is related to centrosome amplification in ovarian cancer
    tumoral     --over  
    in gastric cancer (GC) multidrug resistant cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a novel prognostic marker for gastric cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    potential therapy target for ovarian carcinoma
    cancerdigestivestomach
    suppression of WDR62 inhibits GC cell growth by inducing G2/M cell cycle arrest
    ANIMAL & CELL MODELS