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FLASH GENE
Symbol WDR6 contributors: mct/npt - updated : 27-08-2009
HGNC name WD repeat domain 6
HGNC id 12758
Location 3p21.31      Physical location : 49.044.636 - 49.053.386
Synonym symbol(s) FLJ10218, FLJ52552, FLJ56107, MGC126756, MGC142027
DNA
TYPE functioning gene
STRUCTURE 8.75 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 4273 - 1151 - Li, Xie (2007)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eleven WD repeats domain, clustered into two distinct groups separated by a putative transmembrane segment
  • HOMOLOGY
    interspecies homolog to Arabidosis t7b11.12
    homolog to S.cerevisiae ypl183c
    Homologene
    FAMILY
  • WD repeat protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text localized in cytoplasm, similar to the localization of STK11 (Xie 2007)
    basic FUNCTION
  • regulation of a wide variety of cellular function (signal transduction, transcription, proliferation)
  • implicated in the cell growth inhibitory pathway of STK11 via regulation of CDKN1B (Xie 2007)
  • may be participates in insulin/IGF-I signaling and the regulation of feeding behavior and longevity in the brain (Chiba 2009)
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • able to interact with STK11 (coexpression of WDR6 and STK11 was able to induce CDKN1B) (Xie 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS