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FLASH GENE
Symbol WDR5B contributors: SGE/npt - updated : 25-06-2010
HGNC name WD repeat domain 5B
HGNC id 17826
Location 3q21.1      Physical location : 122.130.699 - 122.134.882
Synonym name WD repeat-containing protein 5B
Synonym symbol(s) FLJ11287, MGC49879
DNA
TYPE functioning gene
STRUCTURE 4.18 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FSTL1 3q13.33 follistatin-like 1 NDUFB4 3q13.33 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa HGD 3q21-q23 homogentisate 1,2-dioxygenase (homogentisate oxidase) MGC23920 GTF2E1 3q21-q24 general transcription factor IIE, polypeptide 1, alpha 56kDa KIAA1006 3q13.33 general transcription factor IIE, polypeptide 1, alpha 56kDa POLQ 3q13.31 polymerase (DNA directed), theta LOC51725 3q21.1 muscle disease-related protein HCLS1 3q13 hematopoietic cell-specific Lyn substrate 1 GOLGB1 3q13 golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1 KIAA0036 3q21.1 golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1 EAF2 3q21.1 ELL associated factor 2 SLC15A2 3p14.3-p14.1 solute carrier family 15 (H+/peptide transporter), member 2 MGC50831 3q21.1 hypothetical protein MGC50831 CD86 3q21 CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) CASR 3q21-q24 calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism) LOC391570 3 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) CSTA 3q21 cystatin A (stefin A) LOC131076 3q21.1 hypothetical LOC131076 E2IG5 3q21.1 growth and transformation-dependent protein WDR5B 3q21.1 WD repeat domain 5B KPNA1 3q21 karyopherin alpha 1 (importin alpha 5) BAL 3q13-q21 B aggressive lymphoma gene LOC151636 FLJ40597 3q21.1 hypothetical protein FLJ40597 LOC339881 3q21.1 similar to eukaryotic initiation factor 4B KIAA1268 3q21.1 KIAA1268 protein HSPBAP1 3q21 HSPB (heat shock 27kDa) associated protein 1 DIRC2 3q21.1 disrupted in renal carcinoma 2 SEMA5B 3q21.1 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B PDIR 3q21.1 for protein disulfide isomerase-related SEC22L2 3q21.1 SEC22 vesicle trafficking protein-like 2 (S. cerevisiae) ADCY5 3q13.2-q21 adenylate cyclase 5 PTPLB 3q21.1 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b MYLK 3q21 myosin, light polypeptide kinase FLJ12892 3q21.2 hypothetical protein FLJ12892 ROPN1 3q21.2 ropporin, rhophilin associated protein 1 HAPIP q21.1-q21.2 huntingtin-associated protein interacting protein (duo)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 4183 - 330 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelial    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven WD repeats
  • HOMOLOGY
    interspecies homolog to murine Wdr5b (83.8pc)
    homolog to rattus Wdr5b (85.1pc)
    Homologene
    FAMILY
  • WD repeat WDR5/wrds family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be mediating protein-protein interactions
  • may function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex
  • Ubl conjugation pathway
  • CELLULAR PROCESS cell life
    protein, degradation
    protein, ubiquitin dependent proteolysis
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • probable part of a cullin-RING E3 protein ligase complex containing CUL4-DDB1 and a substrate-recruiting component (DCAF)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CUL4 and DDB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS