a component
| formation of a stable USP1/WDR48 protein complex, activating FANCD2 , and can deubiquitinate PCNA |
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part of USP12·WDR48·WDR20 complex (potentially involved in other types of transcriptional regulation) |
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USP1/WDR48 complex is a regulator of the cellular response to DNA damage |
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similar to PHLPP1 function, WDR48 and USP12 negatively regulate AKT1 activation and thus promote cellular apoptosis |
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USP1/WDR48 complex promotes stem cell conservation and regulation of DNA damage repair |
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USP1-WDR48 complex is a potential target for the prevention of viral diseases |
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USP12/WDR48/WDR20 complex dynamically shuttles between the plasma membrane, cytoplasm and nucleus |
protein
| interacting with WDR20 (WDR20, a WD40-repeat containing protein, is a common binding partner of WDR48, USP12, and USP46) |
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binds and stimulates three deubiquitinating enzymes: USP1, USP12, and USP46 |
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ATAD5 specifically directs USP1-WDR48 complex for PCNA deubiquitination |
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serine phosphorylation is critical for the activation of USP1 and its interaction with WDR48 |
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important regulatory role of the USP1-WDR48 complex in HR (homologous recombination) repair through its regulation of the FANCD2-ubiquitinated (Ub) and PCNA-Ub cellular pools |
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USP12, in complex with WDR48 and WDR20, deubiquitinates the AR to enhance receptor stability and transcriptional activity |
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WDR48 and USP12 are novel PHLPP1 regulators and potential suppressors of tumor cell survival |
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USP1 amino acid motif 420-520 is necessary and sufficient for WDR48 binding |
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WDR48 interacts with the USP46 fingers subdomain via a relatively small, highly polar surface on the top center of the WDR48 beta propeller |
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USP12 is known to require the co-factors WDR48 and WDR20 for catalytic activity |
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efficient USP1 activity requires binding to its cofactor USP1-associated factor 1 (WDR48), and the USP1-WDR48 deubiquitinase complex has important roles in regulating DNA damage-related processes |
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WDR48 and WDR20 interact with USP12 at two distinct sites far from its catalytic center |
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USP1-WDR48 complex promotes homologous recombination (HR) repair via multiple mechanisms: through FANCD2 deubiquitination, as well as by interacting with RAD51AP1 |
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USP46 is regulated by two WD40-repeat (WDR) proteins, WDR48/UAF1 and WDR20 |
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mechanistically, USP1 and WDR48 bound to TBK1, removed its K48-linked polyubiquitination, and then reversed the degradation process of TBK1 |
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