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FLASH GENE
Symbol WDR33 contributors: mct - updated : 23-03-2020
HGNC name WD repeat domain 33
HGNC id 25651
Location 2q14.3      Physical location : 128.461.807 - 128.568.761
Synonym name
  • WD 40 repeats protein expressed during spermatogenesis
  • WD repeat-containing protein of 146 kDa
  • Synonym symbol(s) WDC146, FLJ11294, nET14
    DNA
    TYPE functioning gene
    STRUCTURE 110.16 kb     22 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 9490 146 1336 - 2014 25301780
    6 - 3183 - 326 - 2014 25301780
    8 - 3583 - 257 - 2014 25301780
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
     thymus    
    Reproductivemale systemtestis  highly
    cell lineage spermatocytes in the pachytene stage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal lysine/arginine-rich motif is a critical determinant of specific AAUAAA motif recognition
  • a collagenous domain
  • seven WD repeats
  • HOMOLOGY
    Homologene
    FAMILY WD repeat protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination
  • CPSF4 and WDR33 directly contact AAUAAA
  • is the large CPSF subunit participating in recognition of the polyadenylation signal
  • CPSF1 functions as an essential scaffold and preorganizes CPSF4 and WDR33 for high-affinity binding to AAUAAA
  • both CPSF4 and WDR33 are required for high-affinity binding of the AAUAAA polyadenylation signal (PAS) RNA, while these two proteins alone and their binary complexes with CPSF1 have much lower affinity for the RNA
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • a core CPSF complex comprising CPSF1, WDR33, CPSF4 and FIP1L1 is sufficient for AAUAAA motif recognition, necessary for 3' polyadenylation, a key step in eukaryotic mRNA biogenesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • likely RBBP6 interacts with the WDR33 and CPSF3 subunits of CPSF, and thus, it is likely that the role of RBBP6 is conserved from yeast to humans
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS